Details of the Drug

General Information of Drug (ID: DMTZ1A5)

Drug Name
13-cis-retinoic acid
Synonyms CRA, UCSD
Indication
Disease Entry ICD 11 Status REF
Glioma 2A00.0 Phase 3 [1]
Azoospermia GB04.0 Phase 2 [2]
Infertility GB04 Phase 2 [2]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
5282379
TTD ID
D07PTH
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor (RAR) TTOD7B3 NOUNIPROTAC Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
2 ClinicalTrials.gov (NCT03323801) RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia. U.S. National Institutes of Health.
3 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7.