Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTZ1A5)

Drug Name

13-cis-retinoic acid Drug Info

Synonyms

CRA, UCSD

Indication

Disease Entry	ICD 11	Status	REF
Glioma	2A00.0	Phase 3	[1]
Azoospermia	GB04.0	Phase 2	[2]
Infertility	GB04	Phase 2	[2]

Cross-matching ID

PubChem CID: 5282379
TTD Drug ID: DMTZ1A5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Retinoic acid receptor (RAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[6]
Adapalene	DMX2358	Acne vulgaris	ED80	Approved	[7]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[8]
Peretinoin	DMESAZK	Hepatocellular carcinoma	2C12.02	Phase 3	[9]
Velac Gel	DMXHI89	Acne vulgaris	ED80	Phase 3	[10]
Amsilarotene	DMOB01U	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
LAS-41001	DMXZ4BK	Rosacea	ED90.0	Discontinued in Preregistration	[12]
IRX-4310	DMUYQH8	Psoriasis vulgaris	EA90	Discontinued in Phase 3	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor (RAR)	TTOD7B3	NOUNIPROTAC	Modulator	[3]

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References

1	Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
2	ClinicalTrials.gov (NCT03323801) RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia. U.S. National Institutes of Health.
3	13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7.
4	Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
5	Retinoids--which dermatological indications will benefit in the near future Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
6	Retinoid agonist isotretinoin ameliorates obstructive renal injury. J Urol. 2003 Oct;170(4 Pt 1):1398-402.
7	A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4.
8	National Cancer Institute Drug Dictionary (drug id 39582).
9	Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191.
10	Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
11	Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. J Clin Oncol. 2002 Aug 15;20(16):3522-32.
12	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027956)
13	An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.