Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU5SAF)

Drug Name

Fructose-6-Phosphate Drug Info

Synonyms

Fructose 6-Phosphate; D-fructose-6-phosphate; fructose-6P; fructose-6-P; D-fructose-6-P; FRUCTOSE -6-PHOSPHATE; fru-6-P; UNII-2012QM764Y; 2012QM764Y; 6814-87-5; keto-D-fructose 6-phosphate; F6R; D-fructose-6P; D-Fructose 6-phosphorate; 6-O-phosphono-D-fructose; Fructose 6-phosphoric acid; SCHEMBL8230; AC1Q28E6; AC1L2C15; CTK5C7413; CHEBI:15946; GSXOAOHZAIYLCY-HSUXUTPPSA-N; Fructose 6-(dihydrogen phosphate); Fructose, 6-(dihydrogen phosphate); EINECS 211-395-6; d-fructose-6-phosphate (open form); ZINC85994845; DB04493; AJ-127870

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 69507
ChEBI ID: CHEBI:15946
CAS Number: CAS 643-13-0
TTD Drug ID: DMU5SAF
INTEDE Drug ID: DR2145

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Fructose-1,6-bisphosphatase (FBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Managlinat dialanetil	DMBYDNE	Type-2 diabetes	5A11	Phase 2	[3]
MB07803	DMHU8SJ	Type-2 diabetes	5A11	Phase 2	[4]
4,6-Dichloro-1H-indole-2-carboxylic acid	DM62XC3	Discovery agent	N.A.	Investigative	[5]
4-(2-amino-1,3-thiazol-4-yl)phenol	DMH5CAQ	Discovery agent	N.A.	Investigative	[6]
1-(4-aminophenylsulfonyl)-3-(2-mercaptoethyl)urea	DM4G0NH	Discovery agent	N.A.	Investigative	[7]
2,5-Anhydroglucitol-1,6-Biphosphate	DMLDHMB	Discovery agent	N.A.	Investigative	[1]
1-(2-mercaptoethyl)-3-(m-tolylsulfonyl)urea	DMIPAMW	Discovery agent	N.A.	Investigative	[7]
4-(4-(4-Nitrophenyl)thiazol-2-ylamino)phenol	DMA9TCD	Discovery agent	N.A.	Investigative	[6]
3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol	DM8EH07	Discovery agent	N.A.	Investigative	[6]
2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol	DMOYT8I	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fructose-1,6-bisphosphatase (FBP)	TTWHDVK	F16P1_HUMAN; F16P2_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
ATP-dependent 6-phosphofructokinase (pfkA)^{Main DME}	DEUZYD1	PFKA_LACDE	Substrate	[2]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7.
3	MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.
4	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22.
7	Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12.