Details of the Drug

General Information of Drug (ID: DMUEWM3)

Drug Name
Technetium (99MTC) mebrofenin
Synonyms
F2NQ468L52; Glycine, N-(2-((3-bromo-2,4,6-trimethylphenyl)amino)-2-oxoethyl)-N-(carboxymethyl)-, technetium-99Tc salt; Mebrofenin / 99Tc; Mebrofenin / technetium-99Tc; Mebrofenin mixture with technetium-99Tc; TECHNETIUM TC-99M MEBROFENIN KIT; Technetium (99Mtc) Mebrofenin; Technetium TC-99M mebrofenin kit; Technetium Tc 99m DISIDA; Technetium Tc 99m diisopropyl-iminodiacetic acid; Technetium Tc 99m mebrofenin; Technetium Tc-99m mebrofenin; UNII-F2NQ468L52
Therapeutic Class
Diagnostic Radiopharmaceutical Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 486.136
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 7
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 6.02 hours [1]
Chemical Identifiers
Formula
C15H19BrN2O5Tc
IUPAC Name
2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetic acid;technetium-99
Canonical SMILES
CC1=CC(=C(C(=C1NC(=O)CN(CC(=O)O)CC(=O)O)C)Br)C.[Tc]
InChI
InChI=1S/C15H19BrN2O5.Tc/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23;/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23);/i;1+1
InChIKey
JLJSYHOPCNWUNE-IEOVAKBOSA-N
Cross-matching ID
PubChem CID
11431716
CAS Number
1415247-71-0
DrugBank ID
DB09137
VARIDT ID
DR01237

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [2]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [2]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [3]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
2 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
3 Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915.
4 Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011 Apr;54(4):738-45.