Details of the Drug

General Information of Drug (ID: DMUOYQR)

Drug Name
AVI-5126
Synonyms Resten-CP; NeuGene (CABG), AVI
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Phase 2 [1]
Drug Type
Antisense drug
Cross-matching ID
TTD ID
D01VDI

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Myc messenger RNA (MYC mRNA) TTNQ5ZP MYC_HUMAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 11 Disease of the circulatory system
Disease Class ICD-11: BA80 Coronary artery disease
The Studied Tissue Peripheral blood
The Studied Disease Coronary artery disease [ICD-11:BA80-BA8Z]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Myc messenger RNA (MYC mRNA) DTT MYC 6.09E-01 0.25 0.37
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT00451256) Safety and Efficacy Study of AVI-5126 When Used on Vein Grafts Before Use in Heart by-Pass Graft Surgery (CABG). U.S. National Institutes of Health.
2 Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model. J Ocul Pharmacol Ther. 2012 Apr;28(2):194-201.