Details of the Drug

General Information of Drug (ID: DMUVON0)

Drug Name
PNT-2258
Indication
Disease Entry ICD 11 Status REF
Diffuse large B-cell lymphoma 2A81 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Drug Type
Antisense drug
Sequence
CACGCACGCGCATCCCCGCCCGTG
Cross-matching ID
TTD ID
D07ACL
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
BCL-2 messenger RNA (BCL2 mRNA) TTFOUV4 BCL2_HUMAN Not Available [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Diffuse large B-cell lymphoma
ICD Disease Classification 2A81
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
BCL-2 messenger RNA (BCL2 mRNA) DTT BCL2 8.27E-03 0.06 0.13
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01733238) Study of PNT2258 for Treatment of Relapsed or Refractory Non-Hodgkin's Lymphoma. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of ProNAi.