Details of the Drug

General Information of Drug (ID: DMV7ZU0)

• Drug Name: GS-6624

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 2	[1]

• Drug Type: Antibody
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 200.38
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 2
  Hydrogen Bond Donor Count; 3
  Hydrogen Bond Acceptor Count; 4
• Chemical Identifiers:
  Formula: C7H6BClO4
  IUPAC Name: 4-borono-3-chlorobenzoic acid
  Canonical SMILES: B(C1=C(C=C(C=C1)C(=O)O)Cl)(O)O
  InChI: InChI=1S/C7H6BClO4/c9-6-3-4(7(10)11)1-2-5(6)8(12)13/h1-3,12-13H,(H,10,11)
  InChIKey: FYDHSNLXZRGWFU-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 17750227
  TTD ID: D09NCU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysyl oxidase homolog 2 (LOXL2)	TTFSUHX	LOXL2_HUMAN	Not Available	[2]

References

• [1] ClinicalTrials.gov (NCT01769196) A Phase 2 Study to See if Simtuzumab (GS-6624) is Safe and Works in Idiopathic Pulmonary Fibrosis (IPF). U.S. National Institutes of Health.
• [2] National Cancer Institute Drug Dictionary (drug id 681814).