Details of the Drug

General Information of Drug (ID: DMVOG8A)

Drug Name

Pemvidutide

Synonyms

Pemvidutide; ALT801; GLXC-26955; 2538014-94-5

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 1	[1]
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Drug Type

Small molecule

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C178H270N38O53
Canonical SMILES: CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCNC(=O)C4C(C(C(C(O4)OCCCCCCCCCCCCCCCCCC(=O)O)O)O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(C)(C)NC(=O)C(CC8=CNC=N8)N
InChI: InChI=1S/C178H270N38O53/c1-15-97(8)142(173(264)199-117(64-69-134(183)224)158(249)206-128(84-106-88-188-112-50-37-36-49-110(106)112)167(258)202-122(78-95(4)5)162(253)200-121(77-94(2)3)161(252)197-118(65-70-135(184)225)160(251)215-143(100(11)219)149(185)240)214-170(261)127(81-103-47-33-30-34-48-103)204-159(250)120(67-72-139(231)232)196-155(246)114(51-38-41-73-179)193-151(242)99(10)191-150(241)98(9)192-154(245)113(53-40-43-75-187-175(266)148-146(238)145(237)147(239)176(269-148)268-76-44-28-26-24-22-20-18-16-17-19-21-23-25-27-35-54-137(227)228)194-157(248)119(66-71-138(229)230)198-168(259)129(86-140(233)234)207-163(254)123(79-96(6)7)201-164(255)124(82-104-55-59-108(221)60-56-104)203-156(247)115(52-39-42-74-180)195-171(262)131(91-217)210-165(256)125(83-105-57-61-109(222)62-58-105)205-169(260)130(87-141(235)236)208-172(263)132(92-218)211-166(257)126(80-102-45-31-29-32-46-102)209-174(265)144(101(12)220)213-136(226)90-189-153(244)116(63-68-133(182)223)212-177(267)178(13,14)216-152(243)111(181)85-107-89-186-93-190-107/h29-34,36-37,45-50,55-62,88-89,93-101,111,113-132,142-148,176,188,217-222,237-239H,15-28,35,38-44,51-54,63-87,90-92,179-181H2,1-14H3,(H2,182,223)(H2,183,224)(H2,184,225)(H2,185,240)(H,186,190)(H,187,266)(H,189,244)(H,191,241)(H,192,245)(H,193,242)(H,194,248)(H,195,262)(H,196,246)(H,197,252)(H,198,259)(H,199,264)(H,200,253)(H,201,255)(H,202,258)(H,203,247)(H,204,250)(H,205,260)(H,206,249)(H,207,254)(H,208,263)(H,209,265)(H,210,256)(H,211,257)(H,212,267)(H,213,226)(H,214,261)(H,215,251)(H,216,243)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)/t97-,98-,99-,100+,101+,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-,145-,146-,147+,148-,176+/m0/s1
InChIKey: PNRXPXQSTNKDJB-VGUJMDGVSA-N

Cross-matching ID

PubChem CID: 167312391
TTD ID: D53BVX

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor (GCGR)	TT9O6WS	GLR_HUMAN	Agonist	[2]
Glucagon-like peptide 1 receptor (GLP1R)	TTVIMDE	GLP1R_HUMAN	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Obesity

ICD Disease Classification

5B81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon-like peptide 1 receptor (GLP1R)	DTT	GLP1R	1.25E-01	0.17	1.26
Glucagon receptor (GCGR)	DTT	GCGR	7.24E-02	-0.52	-0.92

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05292911) A 12-Week Extension Study of ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With Non-alcoholic Fatty Liver Disease (NAFLD). U.S.National Institutes of Health.
2	Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis. Sci Rep. 2022 Apr 23;12(1):6666.