Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY9ZAS)

Drug Name

EUK-189 Drug Info

Synonyms

EUK-189 (topical formulation, radiation burns); EUK-189 (topical formulation, radiation burns), Minerva/Proteome; EUK-189 (topicalformulation, radiation burns), Minerva/Tyrian

Indication

Disease Entry	ICD 11	Status	REF
Skin burns	ME65.0	Phase 1	[1]

Cross-matching ID

PubChem CID: 146157762
TTD Drug ID: DMY9ZAS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Superoxide dismutase Cu-Zn (SOD Cu-Zn)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofersen	DM0AEDT	Amyotrophic lateral sclerosis	8B60.0	Approved	[2]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[3]
Tempol	DMUQH78	Spinal cord injury	ND51.2	Phase 2	[4]
Superoxide dismutase	DMSWPA6	Myocardial infarction	BA41-BA43	Phase 2	[5]
Midismase	DMGCRKY	Cerebral infarction	8B11.5Z	Phase 2	[6]
Methoxyestradiol	DMHSL87	N. A.	N. A.	Phase 2	[7]
ATN-224	DMQJ5DV	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
PC-SOD	DMUHDX3	Interstitial lung disease	CB0Z	Phase 2	[6]
APN-201	DMV7Q6X	Dermatitis	EA80-EA89	Phase 1/2	[8]
AEOL-10150	DM13YRT	Multiple sclerosis	8A40	Preclinical	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Catalase (CAT)	TTPS279	CATA_HUMAN	Modulator	[1]
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Modulator	[1]

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References

1	Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
4	The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):29-34.
5	Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36.
6	A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis
7	Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem. 2003 Jan 3;278(1):407-14.
8	Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59.
9	AEOL-10150 (Aeolus). Curr Opin Investig Drugs. 2006 Jan;7(1):70-80.