Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTAKRNM)

DTP Name Monocarboxylate transporter 4 (SLC16A3)
Gene Name SLC16A3
UniProt ID
O15427 (MOT4_HUMAN)
VARIDT ID
DTD0107
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms MCT 4; MCT4; SLC16A3; Solute carrier family 16 member 3
DTP Family Major Facilitator Superfamily (MFS)
Monocarboxylate Transporter (MCT) Family
Tissue Specificity Highly expressed in skeletal muscle.
Sequence
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Function
This proton-linked monocarboxylate transporter catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Endogenous Substrate(s) Monocarboxylates; Lactate; pyruvate; Branched-chain oxo acids
TCDB ID
2.A.1.13.6
Gene ID
9123
KEGG Pathway
Central carbon metabolism in cancer (hsa05230 )
Reactome Pathway
Proton-coupled monocarboxylate transport (R-HSA-433692 )
Pyruvate metabolism (R-HSA-70268 )
Basigin interactions (R-HSA-210991 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Milchsaure DM462BT Pruritus EC90 Investigative [1]
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The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Monocarboxylate transporter 4 (SLC16A3) DTT Info
DTP DTT Type Literature-reported

References

1 The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J. 2000 Aug 15;350 Pt 1:219-27.