Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTH9SQJ)

DTP Name Glycerol-3-phosphate permease (SLC37A1)
Gene Name SLC37A1
UniProt ID
P57057 (G6PT2_HUMAN)
VARIDT ID
DTD0322
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Synonyms G-3-P permease; G3PP; Glucose-6-phosphate exchanger SLC37A1; SLC37A1; Solute carrier family 37 member 1
DTP Family Major Facilitator Superfamily (MFS)
Organophosphate:Pi Antiporter (OPA) Family
Tissue Specificity Expressed in numerous tissues, with highestexpression in pancreas, kidney, bone marrow, spleen, liver, smallintestine, as well as in fetal brain, liver and spleen.
Sequence
MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEAD
VRFSSQNRKSGSAAPHQLPDNETDCGWAPFDKNNYQQLLGALDYSFLCAYAVGMYLSGII
GERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCL
GNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLF
LIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKNKPLDPEMQCLLLSDGKGSIH
PNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHL
DAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE
ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGP
LLAGLLSPSGWSNVFYMLMFADACALLFLIRLIHKELSCPGSATGDQVPFKEQ
Function
This transporter may transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase.
Endogenous Substrate(s) Glycerol-3-phosphate
TCDB ID
2.A.1.4.7
Gene ID
54020
Reactome Pathway
Gluconeogenesis (R-HSA-70263 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phosphate DMUXQG7 Constipation DD91.1 Approved [1]
------------------------------------------------------------------------------------
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glucose-6-Phosphate DMKY1L4 N. A. N. A. Phase 1 [1]
------------------------------------------------------------------------------------

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.18E-28 2.45E-01 1.35E+00
Adrenocortical carcinoma 2D11.Z Kidney 5.49E-04 -2.67E-01 -1.30E+00
Alopecia ED70 Skin from scalp 9.47E-02 6.24E-02 2.56E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.06E-01 -2.41E-02 -1.65E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 5.17E-01 8.22E-03 5.43E-02
Aortic stenosis BB70 Calcified aortic valve 6.31E-01 3.25E-02 9.98E-02
Apnea 7A40 Hyperplastic tonsil 8.18E-01 -3.53E-01 -1.24E+00
Arthropathy FA00-FA5Z Peripheral blood 9.73E-01 4.75E-02 5.64E-01
Asthma CA23 Nasal and bronchial airway 8.17E-04 2.46E-01 4.07E-01
Atopic dermatitis EA80 Skin 9.06E-01 -3.41E-02 -2.26E-01
Autism 6A02 Whole blood 6.74E-01 9.24E-03 5.22E-02
Autoimmune uveitis 9A96 Peripheral monocyte 5.13E-01 3.62E-02 2.16E-01
Autosomal dominant monocytopenia 4B04 Whole blood 8.94E-01 3.31E-02 1.81E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.63E-07 1.73E-01 7.22E-01
Batten disease 5C56.1 Whole blood 7.32E-01 8.65E-02 4.16E-01
Behcet's disease 4A62 Peripheral blood 4.83E-01 5.46E-02 4.61E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.20E-01 -2.88E-02 -2.21E-01
Bladder cancer 2C94 Bladder tissue 1.50E-03 5.62E-01 2.49E+00
Breast cancer 2C60-2C6Z Breast tissue 4.55E-118 5.35E-01 2.23E+00
Cardioembolic stroke 8B11.20 Whole blood 3.09E-03 1.36E-01 6.62E-01
Cervical cancer 2C77 Cervical tissue 7.65E-05 -2.78E-01 -1.42E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.36E-01 4.81E-02 2.22E-01
Chronic hepatitis C 1E51.1 Whole blood 1.17E-01 -9.87E-02 -7.16E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 4.38E-01 -1.13E-02 -7.56E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 6.61E-01 4.38E-02 2.30E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.88E-01 1.32E-01 7.16E-01
Colon cancer 2B90 Colon tissue 5.51E-50 -3.63E-01 -1.75E+00
Coronary artery disease BA80-BA8Z Peripheral blood 1.18E-02 2.68E-01 2.20E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.90E-01 4.17E-02 1.26E-01
Endometriosis GA10 Endometrium tissue 8.38E-01 4.18E-03 1.04E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.66E-02 -1.56E-01 -1.86E+00
Familial hypercholesterolemia 5C80.00 Whole blood 1.73E-01 1.60E-01 9.70E-01
Gastric cancer 2B72 Gastric tissue 2.79E-01 3.14E-01 6.65E-01
Glioblastopma 2A00.00 Nervous tissue 5.82E-08 -9.77E-02 -4.24E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 4.29E-01 -2.22E-02 -9.32E-02
Head and neck cancer 2D42 Head and neck tissue 2.04E-46 -7.52E-01 -2.53E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.45E-01 -2.11E-02 -1.03E-01
Huntington's disease 8A01.10 Whole blood 4.27E-02 7.47E-02 7.37E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.22E-01 8.55E-02 2.23E-01
Immunodeficiency 4A00-4A20 Peripheral blood 7.46E-01 -1.56E-02 -1.94E-01
Influenza 1.00E+30 Whole blood 1.57E-01 2.60E-01 1.17E+00
Interstitial cystitis GC00.3 Bladder tissue 6.15E-01 -6.78E-02 -1.62E+00
Intracranial aneurysm 8B01.0 Intracranial artery 5.98E-01 4.97E-02 2.38E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.52E-01 -5.92E-02 -2.70E-01
Ischemic stroke 8B11 Peripheral blood 6.63E-01 6.30E-02 4.04E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 5.43E-01 4.03E-02 1.76E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.61E-01 5.33E-02 1.57E-01
Lateral sclerosis 8B60.4 Skin 3.52E-01 1.77E-01 9.94E-01
Liver cancer 2C12.0 Liver tissue 1.17E-04 1.07E-01 4.56E-01
Liver failure DB99.7-DB99.8 Liver tissue 6.29E-02 2.18E-01 8.11E-01
Lung cancer 2C25 Lung tissue 3.54E-03 -4.92E-02 -2.40E-01
Lupus erythematosus 4A40 Whole blood 8.31E-01 -2.73E-02 -7.34E-02
Major depressive disorder 6A70-6A7Z Whole blood 3.66E-01 2.40E-03 1.34E-02
Major depressive disorder 6A70-6A7Z Hippocampus 5.05E-01 -5.97E-02 -4.45E-01
Melanoma 2C30 Skin 7.41E-02 -1.11E-01 -2.20E-01
Multiple myeloma 2A83.1 Bone marrow 2.79E-03 -3.00E-01 -1.34E+00
Multiple myeloma 2A83.1 Peripheral blood 2.73E-01 -1.30E-01 -8.59E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.41E-01 9.63E-02 4.18E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.10E-01 6.08E-02 3.26E-01
Myelofibrosis 2A20.2 Whole blood 6.71E-01 -4.13E-02 -4.05E-01
Myocardial infarction BA41-BA50 Peripheral blood 1.64E-01 6.32E-02 1.80E-01
Myopathy 8C70.6 Muscle tissue 1.82E-02 1.93E-01 1.28E+00
Neonatal sepsis KA60 Whole blood 2.05E-12 -2.37E-01 -1.17E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.81E-01 -6.94E-02 -4.64E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 8.81E-01 2.96E-02 1.54E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 4.74E-02 9.79E-02 1.37E+00
Olive pollen allergy CA08.00 Peripheral blood 2.44E-01 -3.09E-01 -6.08E-01
Oral cancer 2B6E Oral tissue 8.47E-08 -3.21E-01 -1.51E+00
Osteoarthritis FA00-FA0Z Synovial tissue 8.45E-01 -9.05E-02 -5.07E-01
Osteoporosis FB83.1 Bone marrow 2.42E-02 4.19E-01 1.82E+00
Ovarian cancer 2C73 Ovarian tissue 1.12E-02 6.47E-01 1.47E+00
Pancreatic cancer 2C10 Pancreas 9.32E-02 1.03E-01 3.52E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 7.62E-01 2.78E-03 3.93E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.44E-01 -6.99E-02 -5.70E-01
Pituitary cancer 2D12 Pituitary tissue 1.17E-05 -3.77E-01 -1.84E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.64E-06 -4.48E-01 -2.69E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.15E-01 4.48E-02 3.92E-01
Polycythemia vera 2A20.4 Whole blood 1.41E-01 -1.66E-02 -1.26E-01
Pompe disease 5C51.3 Biceps muscle 3.37E-03 3.65E-01 1.82E+00
Preterm birth KA21.4Z Myometrium 8.42E-01 -7.42E-02 -6.30E-01
Prostate cancer 2C82 Prostate 2.74E-01 1.45E-01 3.22E-01
Psoriasis EA90 Skin 9.07E-01 -6.93E-03 -3.37E-02
Rectal cancer 2B92 Rectal colon tissue 8.77E-06 -2.51E-01 -3.06E+00
Renal cancer 2C90-2C91 Kidney 2.45E-02 1.34E-01 8.10E-01
Retinoblastoma 2D02.2 Uvea 2.14E-05 7.05E-01 4.17E+00
Rheumatoid arthritis FA20 Synovial tissue 3.25E-01 -7.79E-02 -3.98E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.06E-01 -1.69E-02 -2.39E-01
Schizophrenia 6A20 Prefrontal cortex 2.51E-01 1.94E-02 7.84E-02
Schizophrenia 6A20 Superior temporal cortex 8.97E-01 8.99E-03 8.16E-02
Scleroderma 4A42.Z Whole blood 1.18E-01 6.54E-02 3.96E-01
Seizure 8A60-8A6Z Whole blood 7.23E-01 3.65E-02 2.04E-01
Sensitive skin EK0Z Skin 7.34E-01 -2.97E-03 -4.21E-02
Sepsis with septic shock 1G41 Whole blood 6.78E-12 -1.86E-01 -7.85E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.76E-01 -1.50E-01 -6.13E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.38E-02 2.75E-01 7.43E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 6.13E-01 1.19E-02 8.06E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.38E-02 -3.20E-01 -1.54E+00
Skin cancer 2C30-2C3Z Skin 9.15E-06 -1.24E-01 -5.78E-01
Thrombocythemia 3B63 Whole blood 4.53E-01 6.64E-02 5.74E-01
Thrombocytopenia 3B64 Whole blood 9.85E-01 6.40E-02 2.04E-01
Thyroid cancer 2D10 Thyroid 2.22E-05 -6.45E-02 -2.86E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.44E-02 -2.55E-01 -1.03E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.85E-01 -9.55E-02 -8.82E-01
Type 2 diabetes 5A11 Liver tissue 8.62E-01 -7.25E-03 -3.37E-02
Ureter cancer 2C92 Urothelium 7.82E-01 -4.68E-02 -3.28E-01
Uterine cancer 2C78 Endometrium tissue 1.21E-02 9.61E-02 2.95E-01
Vitiligo ED63.0 Skin 3.35E-01 6.44E-02 1.06E+00
------------------------------------------------------------------------------------
⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157.