Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTPJBD5)

DTP Name Sodium-coupled neutral amino acid transporter 4 (SLC38A4)
Gene Name SLC38A4
UniProt ID
Q969I6 (S38A4_HUMAN)
VARIDT ID
DTD0331
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms
ATA3; Amino acid transporter A3; NAT3; Na(+)-coupled neutral amino acid transporter 4; PAAT; SLC38A4; SNAT4; Solute carrier family 38 member 4; System A amino acid transporter 3; System N amino acid transporter 3
DTP Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Detected in embryonic and adult liver, and atlower levels in adult muscle, kidney and pancreas. Detected inplacenta syncytiotrophoblasts throughout gestation. Detected infetal blood vessels.
Sequence
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH
Function
This sodium-dependent transporter mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6. 5, intermediate at pH 7. 0 and highest between pH 7. 5 and 8. 5.
Endogenous Substrate(s) Alanine; Histidine; Cysteine; Asparagine; Serine; Glycine; Valine; Threonine; Glutamine; Methionine
TCDB ID
2.A.18.6.17
Gene ID
55089
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-alanine DMZDN4W Dietary shortage 5B5K Approved [1]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 9.90E-04 3.66E-02 4.04E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.17E-01 -3.86E-02 -1.73E-01
Alopecia ED70 Skin from scalp 1.59E-01 1.35E-02 4.04E-02
Alzheimer's disease 8A20 Entorhinal cortex 1.38E-01 -1.10E-02 -1.17E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.27E-02 -7.92E-02 -1.10E+00
Aortic stenosis BB70 Calcified aortic valve 8.21E-01 5.83E-02 1.60E-01
Apnea 7A40 Hyperplastic tonsil 1.92E-01 -1.44E-01 -1.38E+00
Arthropathy FA00-FA5Z Peripheral blood 2.02E-01 6.41E-02 9.97E-01
Asthma CA23 Nasal and bronchial airway 4.90E-05 -2.87E-01 -2.08E-01
Atopic dermatitis EA80 Skin 9.96E-04 -1.59E-01 -1.32E+00
Autism 6A02 Whole blood 5.37E-01 -1.51E-02 -1.77E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.58E-01 -4.13E-03 -3.63E-02
Autosomal dominant monocytopenia 4B04 Whole blood 3.94E-01 -3.19E-02 -3.98E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.63E-04 -1.00E-01 -4.57E-01
Batten disease 5C56.1 Whole blood 4.11E-01 6.62E-02 1.36E+00
Behcet's disease 4A62 Peripheral blood 4.40E-01 -2.74E-02 -3.51E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.07E-01 3.46E-03 3.87E-02
Bladder cancer 2C94 Bladder tissue 6.07E-01 -3.04E-01 -4.22E-01
Breast cancer 2C60-2C6Z Breast tissue 1.84E-05 -8.38E-02 -2.77E-01
Cardioembolic stroke 8B11.20 Whole blood 1.78E-01 -5.65E-02 -2.34E-01
Cervical cancer 2C77 Cervical tissue 6.36E-01 -2.57E-02 -1.48E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.34E-01 -4.63E-03 -4.65E-02
Chronic hepatitis C 1E51.1 Whole blood 6.12E-01 -9.23E-03 -6.76E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 2.04E-01 4.21E-02 4.29E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.08E-03 -7.91E-02 -6.04E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.73E-01 -2.84E-02 -5.61E-01
Colon cancer 2B90 Colon tissue 1.45E-25 -1.63E+00 -1.23E+00
Coronary artery disease BA80-BA8Z Peripheral blood 4.78E-01 -6.55E-02 -4.96E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.76E-02 4.57E-02 3.78E-01
Endometriosis GA10 Endometrium tissue 2.06E-01 -4.07E-02 -4.32E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.67E-01 2.22E-02 4.47E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.48E-01 9.17E-03 8.75E-02
Gastric cancer 2B72 Gastric tissue 2.12E-02 6.84E-02 1.23E+00
Glioblastopma 2A00.00 Nervous tissue 7.09E-01 -3.77E-02 -3.66E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.91E-02 -1.22E-01 -7.11E-01
Head and neck cancer 2D42 Head and neck tissue 8.89E-02 -1.99E-02 -7.69E-02
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.81E-01 8.17E-03 3.54E-02
Huntington's disease 8A01.10 Whole blood 2.16E-01 2.30E-02 3.42E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.81E-01 -9.46E-02 -8.75E-01
Immunodeficiency 4A00-4A20 Peripheral blood 2.08E-01 5.11E-02 7.82E-01
Influenza 1.00E+30 Whole blood 4.88E-01 3.38E-02 5.78E-01
Interstitial cystitis GC00.3 Bladder tissue 7.25E-02 -6.09E-01 -8.37E-01
Intracranial aneurysm 8B01.0 Intracranial artery 3.48E-01 4.62E-02 2.45E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.70E-01 -1.40E-01 -4.55E-01
Ischemic stroke 8B11 Peripheral blood 5.87E-01 5.13E-03 6.59E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 2.36E-03 1.32E-01 4.21E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 3.03E-01 -1.79E-02 -2.51E-01
Lateral sclerosis 8B60.4 Skin 3.60E-01 -1.01E-01 -1.92E-01
Liver cancer 2C12.0 Liver tissue 3.40E-13 -2.20E+00 -1.63E+00
Liver failure DB99.7-DB99.8 Liver tissue 2.47E-04 -3.98E+00 -7.65E+00
Lung cancer 2C25 Lung tissue 3.66E-24 2.79E-02 2.37E-01
Lupus erythematosus 4A40 Whole blood 3.12E-06 3.94E-02 2.83E-01
Major depressive disorder 6A70-6A7Z Whole blood 5.32E-01 -1.08E-02 -6.17E-02
Major depressive disorder 6A70-6A7Z Hippocampus 4.20E-01 1.96E-02 2.18E-01
Melanoma 2C30 Skin 1.24E-02 -6.67E-01 -1.04E+00
Multiple myeloma 2A83.1 Bone marrow 7.47E-03 -1.70E-01 -1.30E+00
Multiple myeloma 2A83.1 Peripheral blood 3.33E-01 4.28E-02 5.44E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 9.49E-01 3.15E-02 9.51E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.50E-01 -2.05E-02 -2.28E-01
Myelofibrosis 2A20.2 Whole blood 3.41E-02 -3.55E-02 -4.98E-01
Myocardial infarction BA41-BA50 Peripheral blood 6.15E-01 -1.76E-02 -3.59E-02
Myopathy 8C70.6 Muscle tissue 5.21E-01 -1.54E-01 -1.70E-01
Neonatal sepsis KA60 Whole blood 9.72E-05 4.47E-02 4.09E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.02E-01 -1.28E-01 -1.38E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.94E-01 -8.78E-02 -8.53E-02
Obesity related type 2 diabetes 5A11 Omental adipose tissue 7.95E-01 -1.21E-02 -7.41E-02
Olive pollen allergy CA08.00 Peripheral blood 2.81E-01 6.03E-02 5.83E-01
Oral cancer 2B6E Oral tissue 1.44E-01 -2.58E-02 -8.11E-02
Osteoarthritis FA00-FA0Z Synovial tissue 9.54E-01 -7.27E-02 -1.76E-01
Osteoporosis FB83.1 Bone marrow 1.47E-01 -3.16E-01 -6.62E-01
Ovarian cancer 2C73 Ovarian tissue 4.50E-05 -8.56E-03 -9.66E-02
Pancreatic cancer 2C10 Pancreas 1.04E-01 -5.36E-01 -5.87E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 8.04E-01 -2.19E-02 -3.98E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 8.36E-01 1.66E-03 2.00E-02
Pituitary cancer 2D12 Pituitary tissue 7.85E-01 5.58E-03 5.03E-02
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.65E-01 1.55E-02 1.56E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.02E-01 -1.38E-01 -3.23E-01
Polycythemia vera 2A20.4 Whole blood 3.98E-04 3.45E-02 4.35E-01
Pompe disease 5C51.3 Biceps muscle 7.92E-03 -6.69E-01 -1.33E+00
Preterm birth KA21.4Z Myometrium 8.43E-01 6.13E-02 1.40E+00
Prostate cancer 2C82 Prostate 8.23E-08 7.81E-01 1.50E+00
Psoriasis EA90 Skin 1.53E-03 3.20E-02 7.91E-02
Rectal cancer 2B92 Rectal colon tissue 7.66E-01 -6.46E-03 -5.66E-03
Renal cancer 2C90-2C91 Kidney 2.19E-02 -7.10E-01 -8.66E-01
Retinoblastoma 2D02.2 Uvea 7.76E-01 -3.59E-02 -5.05E-01
Rheumatoid arthritis FA20 Synovial tissue 2.54E-01 -5.19E-02 -9.35E-02
Rhinovirus infection CA42.1 Nasal epithelium tissue 8.11E-01 -6.96E-03 -5.83E-02
Schizophrenia 6A20 Prefrontal cortex 4.93E-01 -1.88E-03 -1.87E-02
Schizophrenia 6A20 Superior temporal cortex 8.64E-01 -2.76E-02 -4.87E-01
Scleroderma 4A42.Z Whole blood 3.22E-01 -3.13E-02 -2.52E-01
Seizure 8A60-8A6Z Whole blood 1.58E-01 -6.40E-02 -7.27E-01
Sensitive skin EK0Z Skin 2.63E-01 -2.65E-02 -1.61E-01
Sepsis with septic shock 1G41 Whole blood 7.92E-03 4.97E-02 3.82E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.07E-02 1.64E-01 1.84E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 9.94E-01 1.74E-02 8.60E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 5.58E-01 1.26E-01 7.01E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.80E-01 -8.31E-03 -1.04E-01
Skin cancer 2C30-2C3Z Skin 8.86E-01 -1.68E-01 -3.91E-01
Thrombocythemia 3B63 Whole blood 9.56E-01 -5.17E-03 -7.43E-02
Thrombocytopenia 3B64 Whole blood 2.08E-01 1.41E-01 1.60E+00
Thyroid cancer 2D10 Thyroid 5.99E-01 -7.62E-02 -4.55E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.47E-01 -9.92E-01 -7.69E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 6.98E-01 -1.67E-02 -1.61E-01
Type 2 diabetes 5A11 Liver tissue 2.90E-01 -3.34E-01 -1.06E+00
Ureter cancer 2C92 Urothelium 1.71E-01 2.16E-02 2.16E-01
Uterine cancer 2C78 Endometrium tissue 1.26E-04 4.42E-02 1.89E-01
Vitiligo ED63.0 Skin 7.48E-01 -1.39E-01 -3.03E-01
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Solute carrier family 38 member 4 (SLC38A4) DTT Info
DTP DTT Type Literature-reported

References

1 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.