Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1NFO3)

DTT Name Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD)
Synonyms
nadD of Escherichia coli (strain K12); Nicotinate mononucleotide adenylyltransferase of Escherichia coli (strain K12); NaMN adenylyltransferase of Escherichia coli (strain K12); Deamido-NAD(+)Nicotinate-nucleotide adenylyltransferase pyrophosphorylase of Escherichia coli (strain K12); Deamido-NAD(+) pyrophosphorylase of Escherichia coli (strain K12); Deamido-NAD(+) diphosphorylase of Escherichia coli (strain K12)
Gene Name Bact nadD
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Kinase
UniProt ID
NADD_ECOLI
TTD ID
T88126
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 2.7.7.18
Sequence
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHML
ELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEY
ETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNIS
ATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
Function Catalyzes the reversible adenylation of nicotinate mononucleotide (namn) to nicotinic acid adenine dinucleotide (naad).
KEGG Pathway
Nicotinate and nicotinamide metabolism (ecj00760 )
Metabolic pathways (ecj01100 )
Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway
MetaCyc:NICONUCADENYLYLTRAN-MON
EcoCyc:NICONUCADENYLYLTRAN-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AC1LJNG0 DM9Q0EC N. A. N. A. Patented [2]
DZ9 DM2HLGC N. A. N. A. Patented [2]
STK696827 DM19GAY N. A. N. A. Patented [2]
------------------------------------------------------------------------------------
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deamido-NAD DMDFRTI N. A. N. A. Investigative [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
------------------------------------------------------------------------------------

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Targeting NAD biosynthesis in bacterial pathogens. US8785499.
3 Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79.