General Information of Drug Therapeutic Target (DTT) (ID: TT2B6EV)

DTT Name Histamine N-methyltransferase (HNMT)
Synonyms Histamine-N-methyltransferase; HNMT; HMT
Gene Name HNMT
DTT Type
Successful target
[1]
BioChemical Class
Methyltransferase
UniProt ID
HNMT_HUMAN
TTD ID
T17448
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.1.1.8
Sequence
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS
SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD
KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
Function Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
KEGG Pathway
Histidine metabolism (hsa00340 )
Reactome Pathway
Histidine catabolism (R-HSA-70921 )
Metabolism of ingested SeMet, Sec, MeSec into H2Se (R-HSA-2408508 )
BioCyc Pathway
MetaCyc:HS07674-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [1]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [2]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoprine DM5GQD7 Advanced cancer 2A00-2F9Z Phase 2 [2]
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2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(L-)-S-adenosyl-L-homocysteine DMDUN83 Discovery agent N.A. Investigative [3]
4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE DM68S9F Discovery agent N.A. Investigative [2]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Histamine N-methyltransferase (HNMT) DME Info
Gene Name HNMT
1 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [4]
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References

1 Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84.
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Histamine pharmacogenomics. Pharmacogenomics. 2009 May;10(5):867-83.