Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TT2B6EV)
DTT Name | Histamine N-methyltransferase (HNMT) | ||||
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Synonyms | Histamine-N-methyltransferase; HNMT; HMT | ||||
Gene Name | HNMT | ||||
DTT Type |
Successful target
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[1] | |||
BioChemical Class |
Methyltransferase
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UniProt ID | |||||
TTD ID | |||||
3D Structure | |||||
EC Number |
EC 2.1.1.8
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Sequence |
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA |
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Function | Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | ||||
KEGG Pathway | |||||
Reactome Pathway | |||||
BioCyc Pathway | |||||
Molecular Interaction Atlas (MIA) of This DTT
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||
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2 Approved Drug(s) Targeting This DTT
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1 Clinical Trial Drug(s) Targeting This DTT
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2 Investigative Drug(s) Targeting This DTT
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The Drug-Metabolizing Enzyme (DME) Role of This DTT
DTT DME Name | Histamine N-methyltransferase (HNMT) | |||||||||||||||||||||||||||
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Gene Name | HNMT | |||||||||||||||||||||||||||
1 Approved Drug(s) Metabolized by This DTT
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References