Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT38DW5)

• DTT Name: Bacterial 16S ribosomal RNA (Bact 16S rRNA)
• Synonyms: RrnS; Plastid 16S rRNA; 16S rRNA
• Gene Name: Bact 16S rRNA
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T71905

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[1]

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxazolidinones	DMBM47Z	Gram-positive bacterial infection	1B74-1G40	Phase 2	[2]
Apramycin	DMU8QD2	Gram-negative bacterial infection	1B74-1G40	Phase 1	[3]

6 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminodeoxykanamycin	DM79E2K	Discovery agent	N.A.	Investigative	[3]
Butirosin B	DMR6GJK	Discovery agent	N.A.	Investigative	[3]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[3]
Hygromycin B	DMEZ92A	Discovery agent	N.A.	Investigative	[3]
Neamine	DMNCU6H	Discovery agent	N.A.	Investigative	[3]
Ribostamycin	DMXWUHA	Discovery agent	N.A.	Investigative	[3]

References

• [1] Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
• [2] Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.
• [3] RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.