Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3MSAO)

• DTT Name: HUMAN cholinesterase (BCHE)
• Synonyms: Pseudocholinesterase; Choline esterase II; CHE1; Butyrylcholine esterase; Acylcholine acylhydrolase
• Gene Name: BCHE
• BioChemical Class: Type-B carboxylesterase/lipase
• UniProt ID: CHLE_HUMAN
• TTD ID: T98711
• EC Number: EC 3.1.1.8
• Sequence:
  MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
  YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
  LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
  FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
  SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
  LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
  GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
  VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
  RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
  KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
  GL
• Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
• Reactome Pathway:
  Synthesis of PC (R-HSA-1483191)
  Synthesis, secretion, and deacylation of Ghrelin (R-HSA-422085)
  Aspirin ADME (R-HSA-9749641)
  Neurotransmitter clearance (R-HSA-112311)

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Butyrylcholine esterase (BCHE) DME Info
• Gene Name: BCHE

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[2]

References

• [1] Hematological Findings and Complications of COVID-19. Am J Hematol. 2020 Apr 13. doi: 10.1002/ajh.25829.
• [2] An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. Chem Biol Interact. 2008 Sep 25;175(1-3):83-7.