Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAZHU0)

• DTT Name: L-lactate dehydrogenase (LDH)
• Synonyms: Renal carcinoma antigen NY-REN; LDH
• Gene Name: LDHA
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Short-chain dehydrogenases reductase
• UniProt ID: LDHA_HUMAN ; LDHB_HUMAN ; LDHC_HUMAN
• TTD ID: T88057
• Sequence:
  MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
  EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
  IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
  HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
  VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
  SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
• Function: Catalyzes the conversion of lactate to pyruvate and back, as it converts NAD+ to NADH and back. Expressed extensively in body tissues, such as blood cells and heart muscle. Functions asa marker of common injuries and disease such as heart failure because it is released during tissue damage
• KEGG Pathway:
  Glycolysis / Gluconeogenesis (hsa00010)
  Cysteine and methionine metabolism (hsa00270)
  Pyruvate metabolism (hsa00620)
  Propanoate metabolism (hsa00640)
  Metabolic pathways (hsa01100)
  HIF-1 signaling pathway (hsa04066)
  Glucagon signaling pathway (hsa04922)
  Central carbon metabolism in cancer (hsa05230)
• Reactome Pathway: Pyruvate metabolism (R-HSA-70268)

Molecular Interaction Atlas (MIA) of This DTT

7 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID	DMJ0654	Discovery agent	N.A.	Investigative	[2]
3-Hydroxyisoxazole-4-Carboxylic Acid	DMKLZXV	Discovery agent	N.A.	Investigative	[1]
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid	DM6WJ4K	Discovery agent	N.A.	Investigative	[1]
4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid	DME29PX	Discovery agent	N.A.	Investigative	[1]
Naphthalene-2,6-disulfonic acid	DMLHWNG	Discovery agent	N.A.	Investigative	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
OXAMATE	DMTYBC9	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.