Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJUWVB)

• DTT Name: Succinate-semialdehyde dehydrogenase (ALDH5A1)
• Synonyms: Succinic dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1
• Gene Name: ALDH5A1
• DTT Type: Successful target; [1]
• BioChemical Class: Aldehyde/oxo donor oxidoreductase
• UniProt ID: SSDH_HUMAN
• TTD ID: T13259
• EC Number: EC 1.2.1.24
• Sequence:
  MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
  TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
  SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
  TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
  AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
  KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
  AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
  EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
  VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
• Function: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
• KEGG Pathway:
  Alanine, aspartate and glutamate metabolism (hsa00250)
  Butanoate metabolism (hsa00650)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Degradation of GABA (R-HSA-916853)
• BioCyc Pathway: MetaCyc:HS03550-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlormerodrin	DMSF4PR	Diagnostic imaging	N.A.	Approved	[2]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[1]

1 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[3]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(4-hydroxyphenyl)prop-2-en-1-one	DM145QS	Discovery agent	N.A.	Investigative	[3]

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info
• Gene Name: ALDH5A1

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[4]

References

• [1] Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
• [4] Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.