Details of the Drug

General Information of Drug (ID: DMBOV5P)

Drug Name

Sodium oxybate

Synonyms

Sodium oxybate; Oxybate sodium; Sodium Oxybutyrate; Anetamin; Sodium 4-hydroxybutyrate; 4-Hydroxybutyric acid sodium salt; Somsanit; 502-85-2; Catabate; Sodium gamma-hydroxybutyrate; Sodium oxybat; Gamma OH; 4-Hydroxybutyrate sodium; Natrium 4-hydroxybutyrat; Sodium Oxybate [USAN]; Sodium-4-hydroxybutyrate; gamma-Hydroxybutyrate sodium; LUMRYZ; gamma-Hydroxy sodium butyrate; Butanoic acid, 4-hydroxy-, monosodium salt; 4-Hydroxybuttersaeure natriumsalz; gamma-Hydroxybutyrate sodium salt; sodium 4-hydroxybutanoate; WY-3478; Oxybate (sodium); EINECS 207-953-3; JZP-6; NSC 84223; gamma-Hydroxybutyric acid, sodium salt; Butanoic acid, 4-hydroxy-, sodium salt; DTXSID3048940; EB 27; Hydroxybutyric acid monosodium salt; 4-Hydroxybutyric acid monosodium salt; NSC-84223; Sodium gammahydroxybutyrate; UNII-7G33012534; WY 3478; Butyric acid, 4-hydroxy-, monosodium salt; DTXCID6028866; GHB.sodium salt; BUTYRIC ACID, 4-HYDROXY-, SODIUM SALT; .gamma.-hydroxybutyrate sodium salt; XYWAV COMPONENT SODIUM OXYBATE; 7G33012534; SODIUM OXYBATE COMPONENT OF XYWAV; Sodium oxybate (USAN); SODIUM OXYBATE (MART.); SODIUM OXYBATE [MART.]; Oxybate, Sodium; Oxybutyrate, Sodium; NSC84223; GHB Sodium Salt (Sodium Gammahydroxybutyrate); 4 Hydroxybutyrate Sodium; NCGC00247714-01; Sodium gamma Hydroxybutyrate; Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,rel-; Xyrem (TN); SCHEMBL61823; SODIUM OXYBATE [HSDB]; SODIUM OXYBATE [VANDF]; DEA No. 2012; CHEMBL1200682; OXYBATE SODIUM [WHO-DD]; SODIUM OXYBATE [EMA EPAR]; XYGBKMMCQDZQOZ-UHFFFAOYSA-M; HMS2091E15; ; A-Hydroxybutyric acid sodium salt; HY-B1187; Tox21_112871; gamma-Hydroxybutyric acid sodium salt; SODIUM OXYBATE [ORANGE BOOK]; Gamma Hydroxybutyric Acid preparations; GHB.sodium salt, 1mg/ml in Methanol; AKOS006221428; CCG-212465; CS-4796; DB09072; CAS-502-85-2; FT-0626615; D05866; H-4040; SODIUM SALT OF GAMMA-HYDROXYBUTYRIC ACID; .GAMMA.-HYDROXYBUTYRATE SODIUM SALT [MI]; Butanoic acid, 4-hydroxy-, sodium salt (1:1); Q7553347; ?-Hydroxybutyric Acid Sodium Salt (1.0 mg/mL in Methanol)

Indication

Disease Entry	ICD 11	Status	REF
Narcolepsy	7A20	Approved	[1]
Narcolepsy type 1	7A20.0	Approved	[2]
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Drug Type

Small molecule

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C4H7NaO3
Canonical SMILES: C(CC(=O)[O-])CO.[Na+]
InChI: InChI=1S/C4H8O3.Na/c5-3-1-2-4(6)7;/h5H,1-3H2,(H,6,7);/q;+1/p-1
InChIKey: XYGBKMMCQDZQOZ-UHFFFAOYSA-M

Cross-matching ID

PubChem CID: 23663870
TTD ID: D40IXR

Combinatorial Drugs (CBD)

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Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Hydroxyacid-oxoacid transhydrogenase (ADHFE1)	DE8RJ3F	HOT_HUMAN	Substrate	[3]
Succinate-semialdehyde dehydrogenase (ALDH5A1)	DE5KEWZ	SSDH_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Gene/Protein Processing	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	FDA Approved Drug Products from FDA Official Website.
2	Sodium oxybate FDA Label
3	Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005;28(6):921-30.
4	Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.
5	Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.