Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMAVJQ)

DTT Name	Solute carrier family 38 member 3 (SLC38A3)
Synonyms	Sodium-coupled neutral amino acid transporter 3; SNAT3; SN1; Na(+)-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; G17
Gene Name	SLC38A3
DTT Type	Literature-reported target	[1]
UniProt ID	S38A3_HUMAN
TTD ID	T75351
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKS SGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEE KTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPC PLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCH PEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVD PFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINL LVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFL LMTMSLSFIIIDWASGTSRHGGNH
Function	Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
KEGG Pathway	Glutamatergic synapse (hsa04724 ) GABAergic synapse (hsa04727 ) Proximal tubule bicarbonate reclamation (hsa04964 )
Reactome Pathway	Amino acid transport across the plasma membrane (R-HSA-352230 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTP Info

Gene Name

SLC38A3

4 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[3]
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1172).
2	Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
3	Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67.
4	Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.