General Information of Drug Therapeutic Target (DTT) (ID: TTWK8D0)

DTT Name Sodium pump subunit alpha-1 (ATP1A1)
Synonyms Sodium/potassium-transporting ATPase alpha1; Sodium pump 1; Na+/K+ ATPase 1; ATP1A1
Gene Name ATP1A1
DTT Type
Successful target
[1]
BioChemical Class
Acid anhydrides hydrolase
UniProt ID
AT1A1_HUMAN
TTD ID
T40800
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 7.2.2.13
Sequence
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS
RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA
TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI
NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR
NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV
FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN
LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA
LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI
PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN
AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA
KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN
DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK
TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED
SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE
ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE
TYY
Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions.
KEGG Pathway
cGMP-PKG signaling pathway (hsa04022 )
cAMP signaling pathway (hsa04024 )
Cardiac muscle contraction (hsa04260 )
Adrenergic signaling in cardiomyocytes (hsa04261 )
Insulin secretion (hsa04911 )
Thyroid hormone synthesis (hsa04918 )
Thyroid hormone signaling pathway (hsa04919 )
Aldosterone-regulated sodium reabsorption (hsa04960 )
Endocrine and other factor-regulated calcium reabsorption (hsa04961 )
Proximal tubule bicarbonate reclamation (hsa04964 )
Salivary secretion (hsa04970 )
Gastric acid secretion (hsa04971 )
Pancreatic secretion (hsa04972 )
Carbohydrate digestion and absorption (hsa04973 )
Protein digestion and absorption (hsa04974 )
Bile secretion (hsa04976 )
Mineral absorption (hsa04978 )
Reactome Pathway
Ion transport by P-type ATPases (R-HSA-936837 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
8 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetyldigitoxin DMHAUO0 Congestive heart failure BD10 Approved [2]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1]
Almitrine DM0SYAN Chronic obstructive pulmonary disease CA22 Approved [3]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [4]
Artemether DM48QOT Malaria 1F40-1F45 Approved [5]
Chloroprocaine DMSOQK1 Anaesthesia 9A78.6 Approved [6]
Deslanoside DMB3ZSK Arrhythmia BC9Z Approved [1]
Lumefantrine DM29GAD Malaria 1F40-1F45 Approved [5]
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⏷ Show the Full List of 8 Approved Drug(s)
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
UNBS-1450 DMR38M4 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
DIGITOXIGENIN DM5AOFW Discovery agent N.A. Investigative [8]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Chronic obstructive pulmonary disease CA23 Lung tissue 4.66E-01 1.00E-02 0.06
Chronic obstructive pulmonary disease CA23 Small airway epithelium 3.31E-01 -0.03 -0.19
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Almitrine, a new kind of energy-transduction inhibitor acting on mitochondrial ATP synthase. Biochim Biophys Acta. 1989 Aug 3;975(3):325-9.
4 The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50.
5 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
6 Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.
7 Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015 Jun 11;6:e1782.
8 17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity r... J Med Chem. 2000 Jun 15;43(12):2332-49.