DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Ivosidenib |
DM8S6T7
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[22] |
Gilteritinib |
DMWQ4MZ
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[22] |
Oliceridine |
DM6MDCF
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Oliceridine. |
Acute pain [MG31]
|
[22] |
Ivabradine |
DM0L594
|
Major |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Ivabradine. |
Angina pectoris [BA40]
|
[23] |
Bedaquiline |
DM3906J
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Bedaquiline. |
Antimicrobial drug resistance [MG50-MG52]
|
[22] |
Levalbuterol |
DM5YBO1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Levalbuterol. |
Asthma [CA23]
|
[24] |
Eribulin |
DM1DX4Q
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Eribulin. |
Breast cancer [2C60-2C6Y]
|
[22] |
PF-04449913 |
DMSB068
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[22] |
Olodaterol |
DM62B78
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Olodaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[24] |
Osilodrostat |
DMIJC9X
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Osilodrostat. |
Cushing syndrome [5A70]
|
[22] |
Deutetrabenazine |
DMUPFLI
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[22] |
Fostemsavir |
DM50ILT
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Fostemsavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[22] |
Rilpivirine |
DMJ0QOW
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[22] |
Polyethylene glycol |
DM4I1JP
|
Major |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[25] |
Crizotinib |
DM4F29C
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Crizotinib. |
Lung cancer [2C25]
|
[22] |
Osimertinib |
DMRJLAT
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Osimertinib. |
Lung cancer [2C25]
|
[22] |
Selpercatinib |
DMZR15V
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Selpercatinib. |
Lung cancer [2C25]
|
[22] |
Vemurafenib |
DM62UG5
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Vemurafenib. |
Melanoma [2C30]
|
[22] |
Siponimod |
DM2R86O
|
Major |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Siponimod. |
Multiple sclerosis [8A40]
|
[22] |
Fingolimod |
DM5JVAN
|
Major |
Increased risk of ventricular arrhythmias by the combination of Lumefantrine and Fingolimod. |
Multiple sclerosis [8A40]
|
[26] |
Ozanimod |
DMT6AM2
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Ozanimod. |
Multiple sclerosis [8A40]
|
[22] |
Entrectinib |
DMMPTLH
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[22] |
Rucaparib |
DM9PVX8
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Rucaparib. |
Ovarian cancer [2C73]
|
[22] |
Triclabendazole |
DMPWGBR
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[22] |
Macimorelin |
DMQYJIR
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Macimorelin. |
Pituitary gland disorder [5A60-5A61]
|
[27] |
Lefamulin |
DME6G97
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Lefamulin. |
Pneumonia [CA40]
|
[28] |
LEE011 |
DMMX75K
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
Triptorelin |
DMTK4LS
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Triptorelin. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
Pitolisant |
DM8RFNJ
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Pitolisant. |
Somnolence [MG42]
|
[22] |
Lenvatinib |
DMB1IU4
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Lenvatinib. |
Thyroid cancer [2D10]
|
[22] |
Cabozantinib |
DMIYDT4
|
Major |
Increased risk of prolong QT interval by the combination of Lumefantrine and Cabozantinib. |
Thyroid cancer [2D10]
|
[22] |
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