Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TTXIGT7)

DTT Name	Zinc transporter 8 (SLC30A8)
Synonyms	ZnT-8; Solute carrier family 30 member 8; SLC30A8
Gene Name	SLC30A8
DTT Type	Literature-reported target				[1]
BioChemical Class	Cation diffusion facilitator
UniProt ID	ZNT8_HUMAN
TTD ID	T12714
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPT EKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFS LWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMII VSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYF KPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSV HSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPD CLFCEDPCD
Function	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
Reactome Pathway	Zinc efflux and compartmentalization by the SLC30 family (R-HSA-435368 ) Insulin processing (R-HSA-264876 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Zinc transporter 8 (SLC30A8) DTP Info

Gene Name

SLC30A8

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zinc salts	DMZ4R3Q	Arthritis	FA20	Approved	[2]
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References

1	Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24.
2	Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24.