Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE7OAB3)

DME Name	N-acetyltransferase 1 (NAT1) DME Info
Gene Name	NAT1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[1]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[2]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[3]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asacolitin	DM3WVPJ	N. A.	N. A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099.
2	N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281.
3	Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat. Evidence for multiplicity of N-acetyltransferases in the intestine. Biochem Pharmacol. 1996 Nov 22;52(10):1613-20.
4	Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.