Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE8RYV5)

• DME Name: NADPH:quinone reductase (CRYZ) DME Info
• Gene Name: CRYZ

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[2]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[3]
Acetyl ethylene	DMUH4N7	N. A.	N. A.	Investigative	[3]
Hexylacrolein	DMBC8KM	N. A.	N. A.	Investigative	[3]
J-009747	DMQSB6N	N. A.	N. A.	Investigative	[3]

References

• [1] Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes. Biochem Pharmacol. 1987 Nov 15;36(22):3879-84.
• [2] Effect of superoxide dismutase on the autoxidation of various hydroquinones--a possible role of superoxide dismutase as a superoxide:semiquinone oxidoreductase. Free Radic Biol Med. 1988;5(2):71-9.
• [3] Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77.