Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEIVKZ8)

• DME Name: NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
• Gene Name: CBR3

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[2]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab emtansine	DMU1LXS	HER2-positive breast cancer	2C60-2C65	Phase 2	[3]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1H-Indole-2,3-dione	DMOZ91H	Discovery agent	N.A.	Investigative	[4]
ACMC-209cv7	DMQCSFB	N. A.	N. A.	Investigative	[2]
Nitrobenzaldehyde	DM4UHB5	N. A.	N. A.	Investigative	[2]
Phenanthrene-9,10-dione	DMG8KS9	Discovery agent	N.A.	Investigative	[5]

References

• [1] Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. J Pharmacol Exp Ther. 2010 Mar;332(3):755-63.
• [2] Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21.
• [3] The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
• [4] Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. Chem Biol Interact. 2009 Mar 16;178(1-3):234-41.
• [5] Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103.