Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEOXTPZ)

• DME Name: Methylenetetrahydrofolate reductase (MTHFR) DME Info
• Gene Name: MTHFR

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[1]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISO-901	DMBQ8CA	N. A.	N. A.	Phase 1	[6]

References

• [1] Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011 Mar;25(3):172-7.
• [2] 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
• [3] Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
• [4] Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9.
• [5] The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
• [6] Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40.