Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DERDQWN)

DME Name	Dihydrotestosterone oxidoreductase (HSD3B1) DME Info
UniProt ID	3BHS1_HUMAN
Gene Name	HSD3B1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[2]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[3]
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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HE2100	DMCP2KH	Thrombocytopenia	3B64	Discontinued in Phase 1	[4]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
17alpha-hydroxypregnenolone	DMT2EPG	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65.
2	Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81.
3	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
4	Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.