Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT3HUVD)

• DTP Name: Organic cation/carnitine transporter 2 (SLC22A5) DTP Info
• Gene Name: OCTN2

Molecule-Related Drug & Molecule List

10 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[2]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[3]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[4]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[5]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[6]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[7]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[3]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[8]
Acetylcarnitine	DM4UE3K	Chronic fatigue syndrome	8E49	Phase 4	[9]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
acetyl-L-carnitine	DM74HGJ	Discovery agent	N.A.	Investigative	[7]
D-carnitine	DMHNAJ7	N. A.	N. A.	Investigative	[10]

References

• [1] Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8.
• [2] Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
• [3] Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95.
• [4] Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244.
• [5] Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos. 2009 Dec;30(9):495-507.
• [6] Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23.
• [7] Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84.
• [8] Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. Drug Metab Pharmacokinet. 2010;25(1):112-9.
• [9] Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37.
• [10] Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol. 2000 Sep;279(3):F584-91.