Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT6MDC9)

• DTP Name: Thiazide-sensitive sodium-chloride cotransporter (SLC12A3) DTP Info
• Gene Name: NCC

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[1]
Metolazone	DMB39LO	Edema	MG29	Approved	[2]

References

• [1] Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9.
• [2] Inhibition of binding of [3H]metolazone to rat kidney membrane by stilbene disulfonates. Biochem Pharmacol. 1991 Jun 1;41(11):1745-50.