DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Scopolamine |
DMOM8AL
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Scopolamine. |
Addictive disorder [6C50-6C5Z]
|
[10] |
Dronedarone |
DMA8FS5
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Dronedarone. |
Angina pectoris [BA40]
|
[11] |
Linezolid |
DMGFPU2
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Linezolid. |
Bacterial infection [1A00-1C4Z]
|
[12] |
Rabeprazole |
DMMZXIW
|
Moderate |
Increased risk of hypomagnesemia by the combination of Metolazone and Rabeprazole. |
Bacterial infection [1A00-1C4Z]
|
[13] |
Cariprazine |
DMJYDVK
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Cariprazine. |
Bipolar disorder [6A60]
|
[14] |
Phenylbutazone |
DMAYL0T
|
Moderate |
Antagonize the effect of Metolazone when combined with Phenylbutazone. |
Chronic pain [MG30]
|
[15] |
Ketoprofen |
DMRKXPT
|
Moderate |
Antagonize the effect of Metolazone when combined with Ketoprofen. |
Chronic pain [MG30]
|
[15] |
Levomilnacipran |
DMV26S8
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Levomilnacipran. |
Chronic pain [MG30]
|
[16] |
Olopatadine |
DMKMWQG
|
Moderate |
Additive CNS depression effects by the combination of Metolazone and Olopatadine. |
Conjunctiva disorder [9A60]
|
[17] |
Sertraline |
DM0FB1J
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Sertraline. |
Depression [6A70-6A7Z]
|
[16] |
Vilazodone |
DM4LECQ
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Vilazodone. |
Depression [6A70-6A7Z]
|
[16] |
Paroxetine |
DM5PVQE
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Paroxetine. |
Depression [6A70-6A7Z]
|
[16] |
Selegiline |
DM6034S
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Selegiline. |
Depression [6A70-6A7Z]
|
[12] |
Vortioxetine |
DM6F1PU
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Vortioxetine. |
Depression [6A70-6A7Z]
|
[16] |
Isocarboxazid |
DMAF1NB
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Isocarboxazid. |
Depression [6A70-6A7Z]
|
[12] |
Milnacipran |
DMBFE74
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Milnacipran. |
Depression [6A70-6A7Z]
|
[16] |
Escitalopram |
DMFK9HG
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Escitalopram. |
Depression [6A70-6A7Z]
|
[16] |
Tranylcypromine |
DMGB5RE
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Tranylcypromine. |
Depression [6A70-6A7Z]
|
[12] |
Desvenlafaxine |
DMHD4PE
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Desvenlafaxine. |
Depression [6A70-6A7Z]
|
[16] |
OPC-34712 |
DMHG57U
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and OPC-34712. |
Depression [6A70-6A7Z]
|
[14] |
Phenelzine |
DMHIDUE
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Phenelzine. |
Depression [6A70-6A7Z]
|
[12] |
Mepenzolate |
DM8YU2F
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Mepenzolate. |
Digestive system disease [DE2Z]
|
[10] |
Oxybutynine |
DMJPBAX
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Oxybutynine. |
Discovery agent [N.A.]
|
[10] |
Carbamazepine |
DMZOLBI
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Carbamazepine. |
Epilepsy/seizure [8A61-8A6Z]
|
[18] |
Eslicarbazepine |
DMZREFQ
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Eslicarbazepine. |
Epilepsy/seizure [8A61-8A6Z]
|
[19] |
Ethacrynic acid |
DM60QMR
|
Moderate |
Increased risk of fluid/electrolyte loss by the combination of Metolazone and Ethacrynic acid. |
Essential hypertension [BA00]
|
[20] |
Nadolol |
DMW6GVL
|
Moderate |
Increased risk of hyperglycemia by the combination of Metolazone and Nadolol. |
Essential hypertension [BA00]
|
[21] |
Mefenamic acid |
DMK7HFI
|
Moderate |
Antagonize the effect of Metolazone when combined with Mefenamic acid. |
Female pelvic pain [GA34]
|
[15] |
Solifenacin |
DMG592Q
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Solifenacin. |
Functional bladder disorder [GC50]
|
[10] |
Tolterodine |
DMSHPW8
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Tolterodine. |
Functional bladder disorder [GC50]
|
[10] |
Propantheline |
DM2EN6G
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Propantheline. |
Gastric ulcer [DA60]
|
[10] |
Dexlansoprazole |
DM1DBV5
|
Moderate |
Increased risk of hypomagnesemia by the combination of Metolazone and Dexlansoprazole. |
Gastro-oesophageal reflux disease [DA22]
|
[13] |
Cisapride |
DMY7PED
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Cisapride. |
Gastro-oesophageal reflux disease [DA22]
|
[22] |
Metipranolol |
DMJMVKI
|
Moderate |
Increased risk of hypertriglyceridemia by the combination of Metolazone and Metipranolol. |
Glaucoma [9C61]
|
[21] |
Levobunolol |
DMTNFCQ
|
Moderate |
Increased risk of hypertriglyceridemia by the combination of Metolazone and Levobunolol. |
Glaucoma [9C61]
|
[21] |
Carvedilol |
DMHTEAO
|
Moderate |
Increased risk of hyperglycemia by the combination of Metolazone and Carvedilol. |
Heart failure [BD10-BD1Z]
|
[21] |
Furosemide |
DMMQ8ZG
|
Moderate |
Increased risk of fluid/electrolyte loss by the combination of Metolazone and Furosemide. |
Heart failure [BD10-BD1Z]
|
[20] |
Bumetanide |
DMRV7H0
|
Moderate |
Increased risk of fluid/electrolyte loss by the combination of Metolazone and Bumetanide. |
Heart failure [BD10-BD1Z]
|
[20] |
Digitoxin |
DMWVIGP
|
Moderate |
Increased risk of hypokalemia by the combination of Metolazone and Digitoxin. |
Heart failure [BD10-BD1Z]
|
[23] |
Procarbazine |
DMIK367
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Procarbazine. |
Hodgkin lymphoma [2B30]
|
[12] |
Acebutolol |
DM0TI4U
|
Moderate |
Increased risk of hyperglycemia by the combination of Metolazone and Acebutolol. |
Hypertension [BA00-BA04]
|
[21] |
Moexipril |
DM26E4B
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Moexipril. |
Hypertension [BA00-BA04]
|
[24] |
Bisoprolol |
DM3UZ95
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Bisoprolol. |
Hypertension [BA00-BA04]
|
[21] |
Captopril |
DM458UM
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Captopril. |
Hypertension [BA00-BA04]
|
[24] |
Nebivolol |
DM7F1PA
|
Moderate |
Increased risk of hyperglycemia by the combination of Metolazone and Nebivolol. |
Hypertension [BA00-BA04]
|
[21] |
Pindolol |
DMD2NV7
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Pindolol. |
Hypertension [BA00-BA04]
|
[21] |
Benazepril |
DMH1M9B
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Benazepril. |
Hypertension [BA00-BA04]
|
[24] |
Labetalol |
DMK8U72
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Labetalol. |
Hypertension [BA00-BA04]
|
[21] |
Enalapril |
DMNFUZR
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Enalapril. |
Hypertension [BA00-BA04]
|
[24] |
Perindopril |
DMOPZDT
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Perindopril. |
Hypertension [BA00-BA04]
|
[24] |
Quinapril |
DMR8H31
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Quinapril. |
Hypertension [BA00-BA04]
|
[24] |
Lisinopril |
DMUOK4C
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Lisinopril. |
Hypertension [BA00-BA04]
|
[24] |
Belladonna |
DM2RBWK
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Belladonna. |
Infectious gastroenteritis/colitis [1A40]
|
[10] |
Meclofenamic acid |
DM05FXR
|
Moderate |
Antagonize the effect of Metolazone when combined with Meclofenamic acid. |
Inflammatory spondyloarthritis [FA92]
|
[15] |
Propiomazine |
DMKY8V1
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Propiomazine. |
Insomnia [7A00-7A0Z]
|
[14] |
ITI-007 |
DMUQ1DO
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and ITI-007. |
Insomnia [7A00-7A0Z]
|
[14] |
Clidinium |
DMUMQZ0
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Clidinium. |
Irritable bowel syndrome [DD91]
|
[10] |
Dicyclomine |
DMZSDGX
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Dicyclomine. |
Irritable bowel syndrome [DD91]
|
[10] |
Porfimer Sodium |
DM7ZWNY
|
Moderate |
Increased risk of photosensitivity reactions by the combination of Metolazone and Porfimer Sodium. |
Lung cancer [2C25]
|
[25] |
Arsenic trioxide |
DM61TA4
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Arsenic trioxide. |
Mature B-cell lymphoma [2A85]
|
[26] |
Propranolol |
DM79NTF
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Propranolol. |
Migraine [8A80]
|
[21] |
Ozanimod |
DMT6AM2
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Ozanimod. |
Multiple sclerosis [8A40]
|
[12] |
Methoxsalen |
DME8FZ9
|
Moderate |
Increased risk of photosensitivity reactions by the combination of Metolazone and Methoxsalen. |
Mycosis fungoides [2B01]
|
[27] |
Promethazine |
DM6I5GR
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Promethazine. |
Nausea/vomiting [MD90]
|
[14] |
Sibutramine |
DMFJTDI
|
Moderate |
Increased risk of hyponatremia by the combination of Metolazone and Sibutramine. |
Obesity [5B80-5B81]
|
[16] |
Levomethadyl Acetate |
DM06HG5
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[28] |
Rofecoxib |
DM3P5DA
|
Moderate |
Antagonize the effect of Metolazone when combined with Rofecoxib. |
Osteoarthritis [FA00-FA05]
|
[15] |
Valdecoxib |
DMAY7H4
|
Moderate |
Antagonize the effect of Metolazone when combined with Valdecoxib. |
Osteoarthritis [FA00-FA05]
|
[15] |
Diclofenac |
DMPIHLS
|
Moderate |
Antagonize the effect of Metolazone when combined with Diclofenac. |
Osteoarthritis [FA00-FA05]
|
[15] |
Naproxen |
DMZ5RGV
|
Moderate |
Antagonize the effect of Metolazone when combined with Naproxen. |
Osteoarthritis [FA00-FA05]
|
[15] |
Etodolac |
DM6WJO9
|
Moderate |
Antagonize the effect of Metolazone when combined with Etodolac. |
Pain [MG30-MG3Z]
|
[15] |
Diflunisal |
DM7EN8I
|
Moderate |
Antagonize the effect of Metolazone when combined with Diflunisal. |
Pain [MG30-MG3Z]
|
[15] |
Ibuprofen |
DM8VCBE
|
Moderate |
Antagonize the effect of Metolazone when combined with Ibuprofen. |
Pain [MG30-MG3Z]
|
[15] |
Flavoxate |
DMKV4NL
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Flavoxate. |
Pain [MG30-MG3Z]
|
[10] |
Piroxicam |
DMTK234
|
Moderate |
Antagonize the effect of Metolazone when combined with Piroxicam. |
Pain [MG30-MG3Z]
|
[15] |
Safinamide |
DM0YWJC
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Safinamide. |
Parkinsonism [8A00]
|
[12] |
Rasagiline |
DM3WKQ4
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Rasagiline. |
Parkinsonism [8A00]
|
[12] |
Biperiden |
DME78OA
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Biperiden. |
Parkinsonism [8A00]
|
[10] |
Methylscopolamine |
DM5VWOB
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Methylscopolamine. |
Peptic ulcer [DA61]
|
[10] |
Esomeprazole |
DM7BN0X
|
Moderate |
Increased risk of hypomagnesemia by the combination of Metolazone and Esomeprazole. |
Peptic ulcer [DA61]
|
[13] |
Bromfenac |
DMKB79O
|
Moderate |
Antagonize the effect of Metolazone when combined with Bromfenac. |
Postoperative inflammation [1A00-CA43]
|
[15] |
Levomepromazine |
DMIKFEL
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Levomepromazine. |
Psychotic disorder [6A20-6A25]
|
[14] |
Fluphenazine |
DMIT8LX
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Fluphenazine. |
Psychotic disorder [6A20-6A25]
|
[27] |
Meloxicam |
DM2AR7L
|
Moderate |
Antagonize the effect of Metolazone when combined with Meloxicam. |
Rheumatoid arthritis [FA20]
|
[15] |
Sulindac |
DM2QHZU
|
Moderate |
Antagonize the effect of Metolazone when combined with Sulindac. |
Rheumatoid arthritis [FA20]
|
[15] |
Oxaprozin |
DM9UB0P
|
Moderate |
Antagonize the effect of Metolazone when combined with Oxaprozin. |
Rheumatoid arthritis [FA20]
|
[15] |
Flurbiprofen |
DMGN4BY
|
Moderate |
Antagonize the effect of Metolazone when combined with Flurbiprofen. |
Rheumatoid arthritis [FA20]
|
[15] |
Fenoprofen |
DML5VQ0
|
Moderate |
Antagonize the effect of Metolazone when combined with Fenoprofen. |
Rheumatoid arthritis [FA20]
|
[15] |
Quetiapine |
DM1N62C
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Quetiapine. |
Schizophrenia [6A20]
|
[14] |
Mesoridazine |
DM2ZGAN
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Mesoridazine. |
Schizophrenia [6A20]
|
[27] |
Thioridazine |
DM35M8J
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Thioridazine. |
Schizophrenia [6A20]
|
[27] |
Aripiprazole |
DM3NUMH
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Aripiprazole. |
Schizophrenia [6A20]
|
[14] |
Iloperidone |
DM6AUFY
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Iloperidone. |
Schizophrenia [6A20]
|
[27] |
Paliperidone |
DM7NPJS
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Paliperidone. |
Schizophrenia [6A20]
|
[27] |
Perphenazine |
DMA4MRX
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Perphenazine. |
Schizophrenia [6A20]
|
[27] |
Molindone |
DMAH70G
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Molindone. |
Schizophrenia [6A20]
|
[14] |
Thiothixene |
DMDINC4
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Thiothixene. |
Schizophrenia [6A20]
|
[14] |
Trifluoperazine |
DMKBYWI
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Trifluoperazine. |
Schizophrenia [6A20]
|
[27] |
Risperidone |
DMN6DXL
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Risperidone. |
Schizophrenia [6A20]
|
[27] |
Amisulpride |
DMSJVAM
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Amisulpride. |
Schizophrenia [6A20]
|
[27] |
Asenapine |
DMSQZE2
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Asenapine. |
Schizophrenia [6A20]
|
[14] |
Pimozide |
DMW83TP
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Pimozide. |
Schizophrenia [6A20]
|
[29] |
Atropine |
DMEN6X7
|
Minor |
Altered absorption of Metolazone due to GI dynamics variation caused by Atropine. |
Unspecific substance harmful effect [NE6Z]
|
[10] |
Methdilazine |
DMAUHQX
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Methdilazine. |
Vasomotor/allergic rhinitis [CA08]
|
[14] |
Trimeprazine |
DMEMV9D
|
Moderate |
Additive hypotensive effects by the combination of Metolazone and Trimeprazine. |
Vasomotor/allergic rhinitis [CA08]
|
[30] |
Amiodarone |
DMUTEX3
|
Major |
Increased risk of ventricular arrhythmias by the combination of Metolazone and Amiodarone. |
Ventricular tachyarrhythmia [BC71]
|
[31] |
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