Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT82KPY)

• DTP Name: Concentrative nucleoside transporter 2 (SLC28A2) DTP Info
• Gene Name: CNT2

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[1]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[2]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[4]
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[5]

References

• [1] Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals.
• [2] Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
• [3] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
• [4] Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6.
• [5] Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 May;163:60-70.