Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTJ0EW4)

DTP Name	Bile salt export pump (ABCB11) DTP Info
UniProt ID	ABCBB_HUMAN
Gene Name	BSEP

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ezetimibe	DM7A8TW	Hypercholesterolaemia	5C80.0	Approved	[1]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[1]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[1]
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[2]
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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[2]
Taurocholic acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[3]
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Molecule Interaction Atlas

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References

1	Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
2	Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82.
3	Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8.