Details of the Drug

General Information of Drug (ID: DM5FSJA)

Drug Name

Glimepiride

Synonyms

Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Approved	[1]
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Therapeutic Class

Hypoglycemic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

490.6

Logarithm of the Partition Coefficient (xlogp)

3.9

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1 h [2]
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Bioavailability: 99% of drug becomes completely available to its intended biological destination(s) [4]
Clearance: The total body clearance of drug is 52.1 +/- 16.0 mL/min [5]
Elimination: Following oral administration of glimepiride in healthy male subjects, approximately 60% of the total radioactivity was recovered in the urine in 7 days, with M1 and M2 accounting for 80-90% of the total radioactivity recovered in the urine [6]
Half-life: The concentration or amount of drug in body reduced by one-half in 5 - 8 hours [7]
Metabolism: The drug is metabolized via the hepatic [7]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.233 micromolar/kg/day [8]
Unbound Fraction: The unbound fraction of drug in plasma is 0.005% [9]
Vd: The volume of distribution (Vd) of drug is 8.8 L [6]
Water Solubility: The ability of drug to dissolve in water is measured as 0.0012 mg/mL [3]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Blood glucose decreased	Not Available	ABCC8	OTCWQ54I	[10]
Blood glucose decreased	Not Available	ABCC9	OTGAXLQN	[10]
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Chemical Identifiers

Formula: C24H34N4O5S
IUPAC Name: 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
Canonical SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
InChI: InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
InChIKey: WIGIZIANZCJQQY-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 3476
ChEBI ID: CHEBI:5383
CAS Number: 261361-60-8
DrugBank ID: DB00222
TTD ID: D0B2GI
VARIDT ID: DR00158
INTEDE ID: DR0777
ACDINA ID: D00302

Combinatorial Drugs (CBD)

Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATP-binding cassette transporter C8 (ABCC8)	TTP835K	ABCC8_HUMAN	Blocker	[11]
ATP-binding cassette transporter C9 (ABCC9)	TTEF5MJ	ABCC9_HUMAN	Blocker	[11]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Bile salt export pump (ABCB11)	DTJ0EW4	ABCBB_HUMAN	Substrate	[12]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)_{Main DME}	DE5IED8	CP2C9_HUMAN	Substrate	[13]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[14]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[14]
ATP-binding cassette sub-family C member 8 (ABCC8)	OTCWQ54I	ABCC8_HUMAN	Drug Response	[10]
ATP-binding cassette sub-family C member 9 (ABCC9)	OTGAXLQN	ABCC9_HUMAN	Drug Response	[10]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[15]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Gene/Protein Processing	[16]
Calpain-10 (CAPN10)	OTS9LJW4	CAN10_HUMAN	Gene/Protein Processing	[16]
Calpain-2 catalytic subunit (CAPN2)	OTIAPE5J	CAN2_HUMAN	Gene/Protein Processing	[16]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[16]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[16]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ATP-binding cassette transporter C9 (ABCC9)	DTT	ABCC9	6.51E-01	0.02	0.06
ATP-binding cassette transporter C9 (ABCC9)	DTT	ABCC9	8.46E-01	0.02	0.22
Bile salt export pump (ABCB11)	DTP	BSEP	3.72E-02	8.26E-02	6.55E-01
Bile salt export pump (ABCB11)	DTP	BSEP	2.15E-02	-1.67E-02	-6.13E-02
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	7.33E-02	5.59E-02	2.99E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	5.65E-03	-7.28E-02	-1.24E-01

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Glimepiride

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Nateglinide	DMLK2QH	Moderate	Decreased metabolism of Glimepiride caused by Nateglinide mediated inhibition of CYP450 enzyme.	Acute diabete complication [5A2Y]	[17]
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Coadministration of a Drug Treating the Disease Different from Glimepiride (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Arn-509	DMT81LZ	Moderate	Increased metabolism of Glimepiride caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[18]
Oxandrolone	DMU9MYJ	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Oxandrolone.	Alcoholic liver disease [DB94]	[19]
Voriconazole	DMAOL2S	Major	Decreased metabolism of Glimepiride caused by Voriconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[19]
Clarithromycin	DM4M1SG	Moderate	Increased plasma concentration of Glimepiride and Clarithromycin due to competitive binding of plasma proteins.	Bacterial infection [1A00-1C4Z]	[20]
Sulfamethoxazole	DMB08GE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulfamethoxazole.	Bacterial infection [1A00-1C4Z]	[19]
Chloramphenicol	DMFXEWT	Moderate	Increased plasma concentration of Glimepiride and Chloramphenicol due to competitive binding of plasma proteins.	Bacterial infection [1A00-1C4Z]	[21]
Linezolid	DMGFPU2	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Linezolid.	Bacterial infection [1A00-1C4Z]	[19]
Nitazoxanide	DMOWLVG	Moderate	Increased plasma concentration of Glimepiride and Nitazoxanide due to competitive binding of plasma proteins.	Bowel habit change [ME05]	[22]
Alpelisib	DMEXMYK	Moderate	Increased metabolism of Glimepiride caused by Alpelisib mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[23]
Fluoxymesterone	DMUHCF1	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fluoxymesterone.	Breast cancer [2C60-2C6Y]	[19]
Fenofibric acid	DMGO2MC	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fenofibric acid.	Cardiovascular disease [BA00-BE2Z]	[19]
Phenylbutazone	DMAYL0T	Moderate	Decreased renal excretion of Glimepiride caused by Phenylbutazone.	Chronic pain [MG30]	[18]
Ketoprofen	DMRKXPT	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Ketoprofen.	Chronic pain [MG30]	[19]
Ardeparin	DMYRX8B	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Ardeparin.	Coronary thrombosis [BA43]	[19]
Mifepristone	DMGZQEF	Moderate	Decreased metabolism of Glimepiride caused by Mifepristone mediated inhibition of CYP450 enzyme.	Cushing syndrome [5A70]	[24]
Aminoglutethimide	DMWFHMZ	Minor	Increased metabolism of Glimepiride caused by Aminoglutethimide mediated induction of CYP450 enzyme.	Cushing syndrome [5A70]	[25]
Lumacaftor	DMCLWDJ	Moderate	Increased metabolism of Glimepiride caused by Lumacaftor mediated induction of CYP450 enzyme.	Cystic fibrosis [CA25]	[26]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Glimepiride caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[27]
MK-8228	DMOB58Q	Moderate	Increased metabolism of Glimepiride caused by MK-8228 mediated induction of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[28]
Aprepitant	DM053KT	Moderate	Increased metabolism of Glimepiride caused by Aprepitant mediated induction of CYP450 enzyme.	Depression [6A70-6A7Z]	[29]
Sertraline	DM0FB1J	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sertraline.	Depression [6A70-6A7Z]	[19]
Fluoxetine	DM3PD2C	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fluoxetine.	Depression [6A70-6A7Z]	[19]
Vilazodone	DM4LECQ	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Vilazodone.	Depression [6A70-6A7Z]	[19]
Paroxetine	DM5PVQE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Paroxetine.	Depression [6A70-6A7Z]	[19]
Selegiline	DM6034S	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Selegiline.	Depression [6A70-6A7Z]	[19]
Vortioxetine	DM6F1PU	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Vortioxetine.	Depression [6A70-6A7Z]	[19]
Isocarboxazid	DMAF1NB	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Isocarboxazid.	Depression [6A70-6A7Z]	[19]
Escitalopram	DMFK9HG	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Escitalopram.	Depression [6A70-6A7Z]	[19]
Tranylcypromine	DMGB5RE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Tranylcypromine.	Depression [6A70-6A7Z]	[19]
Phenelzine	DMHIDUE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Phenelzine.	Depression [6A70-6A7Z]	[19]
PMID28454500-Compound-96	DM2A75P	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and PMID28454500-Compound-96.	Discovery agent [N.A.]	[19]
PMID28870136-Compound-49	DMTUC9E	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and PMID28870136-Compound-49.	Discovery agent [N.A.]	[19]
Mefenamic acid	DMK7HFI	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Mefenamic acid.	Female pelvic pain [GA34]	[19]
Miconazole	DMPMYE8	Major	Decreased metabolism of Glimepiride caused by Miconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Omeprazole	DM471KJ	Minor	Decreased metabolism of Glimepiride caused by Omeprazole mediated inhibition of CYP450 enzyme.	Gastro-oesophageal reflux disease [DA22]	[30]
Nizatidine	DMGFV3Z	Moderate	Decreased absorption of Glimepiride due to altered gastric pH caused by Nizatidine.	Gastro-oesophageal reflux disease [DA22]	[31]
Cimetidine	DMH61ZB	Moderate	Decreased absorption of Glimepiride due to altered gastric pH caused by Cimetidine.	Gastro-oesophageal reflux disease [DA22]	[31]
Sunitinib	DMCBJSR	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sunitinib.	Gastrointestinal stromal tumour [2B5B]	[19]
Sulfinpyrazone	DMEV954	Moderate	Decreased metabolism of Glimepiride caused by Sulfinpyrazone.	Gout [FA25]	[18]
Rifampin	DMA8J1G	Moderate	Increased metabolism of Glimepiride caused by Rifampin mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[32]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Glimepiride caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[33]
Etravirine	DMGV8QU	Moderate	Decreased metabolism of Glimepiride caused by Etravirine mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[34]
Gemfibrozil	DMD8Q3J	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Gemfibrozil.	Hyper-lipoproteinaemia [5C80]	[19]
Fenofibrate	DMFKXDY	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fenofibrate.	Hyper-lipoproteinaemia [5C80]	[19]
Clofibrate	DMPC1J7	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Clofibrate.	Hyper-lipoproteinaemia [5C80]	[19]
Moexipril	DM26E4B	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Moexipril.	Hypertension [BA00-BA04]	[19]
Captopril	DM458UM	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Captopril.	Hypertension [BA00-BA04]	[19]
Trandolapril	DM4L6EU	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Trandolapril.	Hypertension [BA00-BA04]	[19]
Methyldopa	DM5I621	Minor	Decreased metabolism of Glimepiride caused by Methyldopa.	Hypertension [BA00-BA04]	[35]
Fosinopril	DM9NJ52	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fosinopril.	Hypertension [BA00-BA04]	[19]
Benazepril	DMH1M9B	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Benazepril.	Hypertension [BA00-BA04]	[19]
Enalapril	DMNFUZR	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Enalapril.	Hypertension [BA00-BA04]	[19]
Perindopril	DMOPZDT	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Perindopril.	Hypertension [BA00-BA04]	[19]
Quinapril	DMR8H31	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Quinapril.	Hypertension [BA00-BA04]	[19]
Lisinopril	DMUOK4C	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Lisinopril.	Hypertension [BA00-BA04]	[19]
Probenecid	DMMFWOJ	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Probenecid.	Inborn purine/pyrimidine/nucleotide metabolism error [5C55]	[19]
Balsalazide	DM7I1T9	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Balsalazide.	Indeterminate colitis [DD72]	[19]
Meclofenamic acid	DM05FXR	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Meclofenamic acid.	Inflammatory spondyloarthritis [FA92]	[36]
Testosterone	DM7HUNW	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Testosterone.	Low bone mass disorder [FB83]	[19]
Porfimer Sodium	DM7ZWNY	Moderate	Increased risk of photosensitivity reactions by the combination of Glimepiride and Porfimer Sodium.	Lung cancer [2C25]	[37]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Glimepiride caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[38]
Chloroquine	DMSI5CB	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Chloroquine.	Malaria [1F40-1F45]	[19]
Hydroxychloroquine	DMSIVND	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Hydroxychloroquine.	Malaria [1F40-1F45]	[19]
Sulphadoxine	DMZI2UF	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulphadoxine.	Malaria [1F40-1F45]	[19]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Glimepiride caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[38]
Nitisinone	DMVS9WQ	Moderate	Decreased metabolism of Glimepiride caused by Nitisinone mediated inhibition of CYP450 enzyme.	Metabolism inborn error [5C50]	[39]
Mecasermin	DM1O3BY	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Mecasermin.	Multiple structural anomalies syndrome [LD2F]	[19]
Rifabutin	DM1YBHK	Moderate	Increased metabolism of Glimepiride caused by Rifabutin mediated induction of CYP450 enzyme.	Mycobacterium infection [1B10-1B21]	[32]
Methoxsalen	DME8FZ9	Moderate	Increased risk of photosensitivity reactions by the combination of Glimepiride and Methoxsalen.	Mycosis fungoides [2B01]	[38]
Imatinib	DM7RJXL	Moderate	Decreased metabolism of Glimepiride caused by Imatinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[40]
Nalmefene	DM4YWCZ	Moderate	Increased plasma concentration of Glimepiride and Nalmefene due to competitive binding of plasma proteins.	Opioid use disorder [6C43]	[21]
Rofecoxib	DM3P5DA	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Rofecoxib.	Osteoarthritis [FA00-FA05]	[19]
Valdecoxib	DMAY7H4	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Valdecoxib.	Osteoarthritis [FA00-FA05]	[19]
Diclofenac	DMPIHLS	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Diclofenac.	Osteoarthritis [FA00-FA05]	[19]
Naproxen	DMZ5RGV	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Naproxen.	Osteoarthritis [FA00-FA05]	[19]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Glimepiride caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[41]
Dextropropoxyphene	DM23HCX	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Dextropropoxyphene.	Pain [MG30-MG3Z]	[36]
Aspirin	DM672AH	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Aspirin.	Pain [MG30-MG3Z]	[36]
Etodolac	DM6WJO9	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Etodolac.	Pain [MG30-MG3Z]	[19]
Diflunisal	DM7EN8I	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Diflunisal.	Pain [MG30-MG3Z]	[19]
Ibuprofen	DM8VCBE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Ibuprofen.	Pain [MG30-MG3Z]	[19]
Nabumetone	DMAT2XH	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Nabumetone.	Pain [MG30-MG3Z]	[19]
Piroxicam	DMTK234	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Piroxicam.	Pain [MG30-MG3Z]	[19]
Rasagiline	DM3WKQ4	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Rasagiline.	Parkinsonism [8A00]	[19]
Ranitidine	DM0GUSX	Moderate	Decreased absorption of Glimepiride due to altered gastric pH caused by Ranitidine.	Peptic ulcer [DA61]	[31]
Esomeprazole	DM7BN0X	Minor	Decreased metabolism of Glimepiride caused by Esomeprazole mediated inhibition of CYP450 enzyme.	Peptic ulcer [DA61]	[30]
Famotidine	DMRL3AB	Moderate	Decreased absorption of Glimepiride due to altered gastric pH caused by Famotidine.	Peptic ulcer [DA61]	[31]
Choline salicylate	DM8P137	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Choline salicylate.	Postoperative inflammation [1A00-CA43]	[19]
Ketorolac	DMI4EL5	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Ketorolac.	Postoperative inflammation [1A00-CA43]	[19]
Bromfenac	DMKB79O	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Bromfenac.	Postoperative inflammation [1A00-CA43]	[19]
Enzalutamide	DMGL19D	Moderate	Increased metabolism of Glimepiride caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[42]
Verteporfin	DMIY6DB	Moderate	Increased risk of photosensitivity reactions by the combination of Glimepiride and Verteporfin.	Psoriasis [EA90]	[18]
Bosentan	DMIOGBU	Moderate	Increased metabolism of Glimepiride caused by Bosentan mediated induction of CYP450 enzyme.	Pulmonary hypertension [BB01]	[43]
Sulfadiazine	DMTW3R8	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulfadiazine.	Rheumatic fever [1B40]	[19]
Salsalate	DM13P4C	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Salsalate.	Rheumatoid arthritis [FA20]	[19]
Sulindac	DM2QHZU	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulindac.	Rheumatoid arthritis [FA20]	[19]
Celecoxib	DM6LOQU	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Celecoxib.	Rheumatoid arthritis [FA20]	[19]
Oxaprozin	DM9UB0P	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Oxaprozin.	Rheumatoid arthritis [FA20]	[19]
Flurbiprofen	DMGN4BY	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Flurbiprofen.	Rheumatoid arthritis [FA20]	[19]
Sulfasalazine	DMICA9H	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulfasalazine.	Rheumatoid arthritis [FA20]	[19]
Fenoprofen	DML5VQ0	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Fenoprofen.	Rheumatoid arthritis [FA20]	[19]
Leflunomide	DMR8ONJ	Moderate	Decreased metabolism of Glimepiride caused by Leflunomide mediated inhibition of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[44]
Indomethacin	DMSC4A7	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Indomethacin.	Rheumatoid arthritis [FA20]	[19]
Tolmetin	DMWUIJE	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Tolmetin.	Rheumatoid arthritis [FA20]	[19]
Salicyclic acid	DM2F8XZ	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Salicyclic acid.	Seborrhoeic dermatitis [EA81]	[36]
Cyclophosphamide	DM4O2Z7	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Cyclophosphamide.	Solid tumour/cancer [2A00-2F9Z]	[19]
Ifosfamide	DMCT3I8	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Ifosfamide.	Solid tumour/cancer [2A00-2F9Z]	[19]
Methyltestosterone	DMWLFGO	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Methyltestosterone.	Solid tumour/cancer [2A00-2F9Z]	[19]
Warfarin	DMJYCVW	Moderate	Increased plasma concentration of Glimepiride and Warfarin due to competitive binding of plasma proteins.	Supraventricular tachyarrhythmia [BC81]	[21]
Clopidogrel	DMOL54H	Minor	Decreased metabolism of Glimepiride caused by Clopidogrel mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[45]
Pramlintide	DM0EZ9Q	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Pramlintide.	Type-1/2 diabete [5A10-5A11]	[19]
Mesalazine	DMOL5IU	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Mesalazine.	Ulcerative colitis [DD71]	[36]
Olsalazine	DMZW9HA	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Olsalazine.	Ulcerative colitis [DD71]	[19]
Sulfamethizole	DMGCHDS	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulfamethizole.	Urinary tract infection [GC08]	[19]
Sulfisoxazole	DMXLT8C	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Sulfisoxazole.	Urinary tract infection [GC08]	[19]
Disopyramide	DM5SYZP	Moderate	Increased risk of hypoglycemia by the combination of Glimepiride and Disopyramide.	Ventricular tachyarrhythmia [BC71]	[19]
-----------


⏷ Show the Full List of 116 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
D&C red no. 27	E00381	83511	Colorant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Poloxamer 188	E00645	Not Available	Emulsifying agent; Solubilizing agent; Surfactant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
--------------------


⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Glimepiride 3 mg tablet	3 mg	Oral Tablet	Oral
Glimepiride 6 mg tablet	6 mg	Oral Tablet	Oral
Glimepiride 2 mg tablet	2 mg	Oral Tablet	Oral
Glimepiride 8 mg tablet	8 mg	Oral Tablet	Oral
Glimepiride 4 mg tablet	4 mg	Oral Tablet	Oral
Glimepiride 1 mg tablet	1 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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