Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTWN7FC)

DTP Name	Multidrug resistance-associated protein 8 (ABCC11) DTP Info
UniProt ID	ABCCB_HUMAN
Gene Name	MRP8

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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4 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[1]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[2]
Tenofovir	DM1IS6U	Human immunodeficiency virus infection	1C62	Approved	[3]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[4]
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Molecule Interaction Atlas

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References

1	ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci. 2010 Nov;101(11):2404-10.
2	Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. Neuroscience. 2006;137(4):1247-57.
3	Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e01725-16.
4	MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003 Aug 8;278(32):29509-14.