Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTZRMK5)

• DTP Name: Multidrug resistance protein 3 (ABCB4) DTP Info
• Gene Name: MDR3

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[1]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1]
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[2]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1]

References

• [1] MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9.
• [2] Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45.