Details of the Drug

General Information of Drug (ID: DM5TVS3)

Drug Name
Vinblastine
Synonyms
Nincaluicolflastine; Rozevin; VLB; Vinblastin; Vinblastina; Vinblastinum; Vincaleucoblastin; Vincaleucoblastine; Vincaleukoblastine; Vincoblastine; Vinblastina [DCIT]; VR-8; Vinblastina (TN); Vinblastine (INN); Vinblastine [INN:BAN]; Vinblastinum [INN-Latin]; NDC 0002-1452-01; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE; (2xi,3beta,4'beta,19xi)-vincaleukoblastine; 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [1]
Anterior urethra cancer N.A. Approved [1]
Extragonadal germ cell tumor N.A. Approved [1]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [1]
Kaposi sarcoma 2B57 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Posterior urethra cancer N.A. Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Testicular cancer 2C80 Approved [1]
Testicular germ cell tumor N.A. Approved [1]
Classic Hodgkin lymphoma N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 811
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 12
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 3.1 mL/min/kg [4]
Elimination
0.5% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 19 hours [4]
Metabolism
The drug is metabolized via the hepatic []
Unbound Fraction
The unbound fraction of drug in plasma is 0.14% [4]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 28 L/kg [4]
Water Solubility
The ability of drug to dissolve in water is measured as 10 mg/mL [3]
Chemical Identifiers
Formula
C46H58N4O9
IUPAC Name
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
Canonical SMILES
CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI
InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChIKey
JXLYSJRDGCGARV-CFWMRBGOSA-N
Cross-matching ID
PubChem CID
13342
CAS Number
865-21-4
DrugBank ID
DB00570
TTD ID
D0W9MM
VARIDT ID
DR00308
INTEDE ID
DR1689
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin beta-2 chain (TUBB2) TTJ2PTI TBB2A_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance protein 3 (ABCB4) DTZRMK5 MDR3_HUMAN Substrate [6]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [7]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [11]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [12]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Drug Response [14]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Drug Response [14]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Drug Response [14]
Actin-binding LIM protein 1 (ABLIM1) OTHXEK3E ABLM1_HUMAN Drug Response [14]
Acyl-coenzyme A thioesterase 13 (ACOT13) OTWRUST1 ACO13_HUMAN Drug Response [14]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Drug Response [14]
ATP synthase subunit e, mitochondrial (ATP5ME) OTADVEE2 ATP5I_HUMAN Drug Response [14]
ATP synthase subunit f, mitochondrial (ATP5MF) OTE4TBG9 ATPK_HUMAN Drug Response [14]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Drug Response [15]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [16]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Vinblastine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Larotrectinib DM26CQR Moderate Decreased metabolism of Vinblastine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [17]
Armodafinil DMGB035 Minor Increased metabolism of Vinblastine caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [18]
LEE011 DMMX75K Moderate Decreased metabolism of Vinblastine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [19]
Etoposide DMNH3PG Minor Decreased metabolism of Vinblastine caused by Etoposide mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [20]
Doxorubicin DMVP5YE Minor Decreased metabolism of Vinblastine caused by Doxorubicin mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [20]
Coadministration of a Drug Treating the Disease Different from Vinblastine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Moderate Increased metabolism of Vinblastine caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [21]
Midostaurin DMI6E0R Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Midostaurin. Acute myeloid leukaemia [2A60] [22]
Gilteritinib DMTI0ZO Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [17]
Siltuximab DMGEATB Moderate Additive myelosuppressive effects by the combination of Vinblastine and Siltuximab. Anemia [3A00-3A9Z] [22]
Dronedarone DMA8FS5 Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Dronedarone. Angina pectoris [BA40] [23]
Voriconazole DMAOL2S Major Decreased clearance of Vinblastine due to the transporter inhibition by Voriconazole. Aspergillosis [1F20] [24]
Posaconazole DMUL5EW Major Decreased metabolism of Vinblastine caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [24]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Vinblastine and Roflumilast. Asthma [CA23] [22]
Ofloxacin DM0VQN3 Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Ofloxacin. Bacterial infection [1A00-1C4Z] [25]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Vinblastine caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [26]
Clarithromycin DM4M1SG Major Decreased clearance of Vinblastine due to the transporter inhibition by Clarithromycin. Bacterial infection [1A00-1C4Z] [24]
Trovafloxacin DM6AN32 Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Trovafloxacin. Bacterial infection [1A00-1C4Z] [25]
Sparfloxacin DMB4HCT Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Sparfloxacin. Bacterial infection [1A00-1C4Z] [25]
Gemifloxacin DMHT34O Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Gemifloxacin. Bacterial infection [1A00-1C4Z] [25]
Norfloxacin DMIZ6W2 Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Norfloxacin. Bacterial infection [1A00-1C4Z] [25]
ABT-492 DMJFD2I Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by ABT-492. Bacterial infection [1A00-1C4Z] [25]
Levofloxacin DMS60RB Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Levofloxacin. Bacterial infection [1A00-1C4Z] [25]
Troleandomycin DMUZNIG Major Decreased clearance of Vinblastine due to the transporter inhibition by Troleandomycin. Bacterial infection [1A00-1C4Z] [24]
Lomefloxacin DMVRH9C Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Lomefloxacin. Bacterial infection [1A00-1C4Z] [25]
Telithromycin DMZ4P3A Major Decreased clearance of Vinblastine due to the transporter inhibition by Telithromycin. Bacterial infection [1A00-1C4Z] [24]
Erdafitinib DMI782S Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Erdafitinib. Bladder cancer [2C94] [27]
Lomustine DMMWSUL Minor Decreased metabolism of Vinblastine caused by Lomustine mediated inhibition of CYP450 enzyme. Brain cancer [2A00] [20]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Vinblastine caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [28]
Tucatinib DMBESUA Major Decreased clearance of Vinblastine due to the transporter inhibition by Tucatinib. Breast cancer [2C60-2C6Y] [24]
Palbociclib DMD7L94 Moderate Decreased metabolism of Vinblastine caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Capecitabine DMTS85L Minor Decreased metabolism of Vinblastine caused by Capecitabine mediated inhibition of CYP450 enzyme. Colorectal cancer [2B91] [20]
Mifepristone DMGZQEF Moderate Decreased metabolism of Vinblastine caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [17]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Vinblastine caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [30]
MK-8228 DMOB58Q Moderate Decreased metabolism of Vinblastine caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [31]
Aprepitant DM053KT Moderate Decreased metabolism of Vinblastine caused by Aprepitant mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [32]
Nefazodone DM4ZS8M Major Decreased metabolism of Vinblastine caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [24]
Primidone DM0WX6I Moderate Increased metabolism of Vinblastine caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Vinblastine caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [34]
Cenobamate DM8KLU9 Moderate Increased metabolism of Vinblastine caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Vinblastine caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [36]
Rufinamide DMWE60C Moderate Increased metabolism of Vinblastine caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [22]
Phenobarbital DMXZOCG Moderate Increased metabolism of Vinblastine caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Tazemetostat DMWP1BH Moderate Increased metabolism of Vinblastine caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [37]
Itraconazole DMCR1MV Major Decreased clearance of Vinblastine due to the transporter inhibition by Itraconazole. Fungal infection [1F29-1F2F] [24]
Miconazole DMPMYE8 Moderate Decreased metabolism of Vinblastine caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [38]
Ketoconazole DMPZI3Q Major Decreased metabolism of Vinblastine caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [24]
Boceprevir DMBSHMF Major Decreased clearance of Vinblastine due to the transporter inhibition by Boceprevir. Hepatitis virus infection [1E50-1E51] [24]
Telaprevir DMMRV29 Major Decreased metabolism of Vinblastine caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [24]
Rifampin DMA8J1G Moderate Accelerated clearance of Vinblastine due to the transporter induction by Rifampin. HIV-infected patients with tuberculosis [1B10-1B14] [33]
Rifapentine DMCHV4I Moderate Accelerated clearance of Vinblastine due to the transporter induction by Rifapentine. HIV-infected patients with tuberculosis [1B10-1B14] [33]
Delavirdine DM3NF5G Major Decreased metabolism of Vinblastine caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [24]
Fosamprenavir DM4W9B3 Major Decreased metabolism of Vinblastine caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [24]
Cobicistat DM6L4H2 Major Decreased clearance of Vinblastine due to the transporter inhibition by Cobicistat. Human immunodeficiency virus disease [1C60-1C62] [24]
Efavirenz DMC0GSJ Moderate Increased metabolism of Vinblastine caused by Efavirenz mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [39]
Saquinavir DMG814N Major Decreased metabolism of Vinblastine caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [24]
Amprenavir DMLMXE0 Major Decreased metabolism of Vinblastine caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [24]
Darunavir DMN3GCH Moderate Decreased metabolism of Vinblastine caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [40]
Atazanavir DMSYRBX Major Decreased metabolism of Vinblastine caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [24]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Vinblastine and Teriflunomide. Hyper-lipoproteinaemia [5C80] [41]
BMS-201038 DMQTAGO Moderate Decreased clearance of Vinblastine due to the transporter inhibition by BMS-201038. Hyper-lipoproteinaemia [5C80] [42]
Cinacalcet DMCX0K3 Moderate Decreased metabolism of Vinblastine caused by Cinacalcet mediated inhibition of CYP450 enzyme. Hyper-parathyroidism [5A51] [17]
Conivaptan DM1V329 Major Decreased metabolism of Vinblastine caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [24]
Tolvaptan DMIWFRL Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Tolvaptan. Hypo-osmolality/hyponatraemia [5C72] [17]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Vinblastine caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [43]
Amobarbital DM0GQ8N Moderate Increased metabolism of Vinblastine caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [33]
Glycerol phenylbutyrate DMDGRQO Moderate Increased metabolism of Vinblastine caused by Glycerol phenylbutyrate mediated induction of CYP450 enzyme. Liver disease [DB90-DB9Z] [22]
Denosumab DMNI0KO Moderate Additive immunosuppressive effects by the combination of Vinblastine and Denosumab. Low bone mass disorder [FB83] [44]
Crizotinib DM4F29C Moderate Decreased metabolism of Vinblastine caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [45]
Brigatinib DM7W94S Moderate Increased metabolism of Vinblastine caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [46]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Vinblastine and Porfimer Sodium. Lung cancer [2C25] [47]
Ceritinib DMB920Z Major Decreased metabolism of Vinblastine caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [24]
PF-06463922 DMKM7EW Moderate Increased metabolism of Vinblastine caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [48]
Osimertinib DMRJLAT Moderate Decreased metabolism of Vinblastine caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [22]
Capmatinib DMYCXKL Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Capmatinib. Lung cancer [2C25] [49]
Selpercatinib DMZR15V Moderate Decreased metabolism of Vinblastine caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [22]
Idelalisib DM602WT Major Decreased metabolism of Vinblastine caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [24]
IPI-145 DMWA24P Moderate Decreased metabolism of Vinblastine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [50]
Blinatumomab DMGECIJ Moderate Decreased metabolism of Vinblastine caused by Blinatumomab mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [51]
LGX818 DMNQXV8 Moderate Increased metabolism of Vinblastine caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [52]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Vinblastine caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [22]
Lasmiditan DMXLVDT Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Lasmiditan. Migraine [8A80] [53]
Exjade DMHPRWG Moderate Decreased metabolism of Vinblastine caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [54]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Vinblastine and Thalidomide. Multiple myeloma [2A83] [55]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Vinblastine and Tecfidera. Multiple sclerosis [8A40] [56]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Vinblastine and Siponimod. Multiple sclerosis [8A40] [17]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Vinblastine and Fingolimod. Multiple sclerosis [8A40] [57]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Vinblastine and Ocrelizumab. Multiple sclerosis [8A40] [58]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Vinblastine and Ozanimod. Multiple sclerosis [8A40] [22]
Rifabutin DM1YBHK Moderate Increased metabolism of Vinblastine caused by Rifabutin mediated induction of CYP450 enzyme. Mycobacterium infection [1B10-1B21] [33]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Vinblastine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [22]
Nilotinib DM7HXWT Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Nilotinib. Myeloproliferative neoplasm [2A20] [59]
Imatinib DM7RJXL Moderate Decreased metabolism of Vinblastine caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [60]
Dasatinib DMJV2EK Moderate Decreased metabolism of Vinblastine caused by Dasatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [61]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive myelosuppressive effects by the combination of Vinblastine and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [62]
Modafinil DMYILBE Minor Increased metabolism of Vinblastine caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [18]
Rolapitant DM8XP26 Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Rolapitant. Nausea/vomiting [MD90] [63]
Entrectinib DMMPTLH Moderate Decreased metabolism of Vinblastine caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [64]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Vinblastine caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [65]
Abametapir DM2RX0I Moderate Decreased metabolism of Vinblastine caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [66]
Lefamulin DME6G97 Moderate Decreased metabolism of Vinblastine caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [67]
Lonafarnib DMGM2Z6 Major Decreased clearance of Vinblastine due to the transporter inhibition by Lonafarnib. Premature ageing appearance [LD2B] [24]
Enzalutamide DMGL19D Moderate Accelerated clearance of Vinblastine due to the transporter induction by Enzalutamide. Prostate cancer [2C82] [68]
Ustekinumab DMHTYK3 Moderate Additive myelosuppressive effects by the combination of Vinblastine and Ustekinumab. Psoriasis [EA90] [22]
Tildrakizumab DMLW9HG Moderate Additive immunosuppressive effects by the combination of Vinblastine and Tildrakizumab. Psoriasis [EA90] [22]
Risankizumab DMM32GT Moderate Additive immunosuppressive effects by the combination of Vinblastine and Risankizumab. Psoriasis [EA90] [22]
Ixekizumab DMXW92T Moderate Additive immunosuppressive effects by the combination of Vinblastine and Ixekizumab. Psoriasis [EA90] [22]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Vinblastine and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [69]
Gatifloxacin DMSL679 Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Gatifloxacin. Respiratory infection [CA07-CA4Z] [25]
Tocilizumab DM7J6OR Moderate Additive myelosuppressive effects by the combination of Vinblastine and Tocilizumab. Rheumatoid arthritis [FA20] [22]
Canakinumab DM8HLO5 Moderate Additive myelosuppressive effects by the combination of Vinblastine and Canakinumab. Rheumatoid arthritis [FA20] [22]
Rilonacept DMGLUQS Moderate Additive myelosuppressive effects by the combination of Vinblastine and Rilonacept. Rheumatoid arthritis [FA20] [22]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Vinblastine and Golimumab. Rheumatoid arthritis [FA20] [70]
Dexamethasone DMMWZET Moderate Increased metabolism of Vinblastine caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [33]
Sarilumab DMOGNXY Moderate Additive immunosuppressive effects by the combination of Vinblastine and Sarilumab. Rheumatoid arthritis [FA20] [22]
Leflunomide DMR8ONJ Major Additive myelosuppressive effects by the combination of Vinblastine and Leflunomide. Rheumatoid arthritis [FA20] [41]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Vinblastine when combined with Anthrax vaccine. Sepsis [1G40-1G41] [71]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Vinblastine caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [22]
Pitolisant DM8RFNJ Moderate Increased metabolism of Vinblastine caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [22]
Fostamatinib DM6AUHV Moderate Decreased clearance of Vinblastine due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [72]
Brilinta DMBR01X Moderate Decreased metabolism of Vinblastine caused by Brilinta mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [22]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Vinblastine and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [69]
Azathioprine DMMZSXQ Moderate Additive myelosuppressive effects by the combination of Vinblastine and Azathioprine. Transplant rejection [NE84] [17]
Tacrolimus DMZ7XNQ Moderate Increased plasma concentrations of Vinblastine and Tacrolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [69]
Cinoxacin DM4EWNS Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Cinoxacin. Urinary tract infection [GC08] [25]
Nalidixic acid DMRM0JV Minor Decreased absorption of Vinblastine due to intestinal mucosa variation caused by Nalidixic acid. Urinary tract infection [GC08] [25]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Vinblastine and Ganciclovir. Virus infection [1A24-1D9Z] [17]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Vinblastine and Valganciclovir. Virus infection [1A24-1D9Z] [17]
⏷ Show the Full List of 122 DDI Information of This Drug

References

1 Vinblastine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6851).
3 BDDCS applied to over 900 drugs
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12 Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
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14 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
15 Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia. Mol Cancer Ther. 2006 Aug;5(8):1986-94.
16 MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. doi: 10.1002/ijc.21013.
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21 Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
22 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
23 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
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26 Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
27 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
28 Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
29 Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
30 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
31 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
32 Charasson V, Haaz MC, Robert J "Determination of Drug Interactions Occurring with the Metabolic Pathways of Irinotecan." Drug Metab Dispos 30 (2002): 731-733. [PMID: 12019202]
33 Product Information. Marqibo (vinCRIStine liposome). Talon Therapeutics Inc, South San Francisco,, CA.
34 Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
35 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
36 Bollini P, Riva R, Albani F, Ida et al "Decreased phenytoin level during antineoplastic therapy: a case report." Epilepsia 24 (1983): 75-8. [PMID: 6822234]
37 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
38 Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
39 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
40 Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
41 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
42 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
43 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
44 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
45 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
46 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
47 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
48 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
49 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
50 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
51 Product Information. Blincyto (blinatumomab). Amgen USA, Thousand Oaks, CA.
52 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
53 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
54 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
55 Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
56 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
57 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
58 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
59 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
60 Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
61 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
62 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
63 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
64 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
65 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
66 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
67 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
68 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
69 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
70 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
71 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
72 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.