Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT48I1Y)

• DTT Name: Placenta growth factor (PlGF) DTT Info
• Gene Name: PGF

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aflibercept	DMT3D5I	Central retinal vein occlusion with macular edema		Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RO-5323441	DMUB3OY	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
TB-403	DMDPBMH	Glioblastoma of brain	2A00.00	Phase 2	[3]
R7334	DMVA186	Macular degeneration	9B78.3	Phase 1	[4]
SFLT-01	DMD2GKF	Macular degeneration	9B78.3	Phase 1	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[6]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo. Cancer Research. 01/2011.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of Roche (2009).
• [5] sFLT01: a novel fusion protein with antiangiogenic activity. Mol Cancer Ther. 2011 Mar;10(3):404-15.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.