General Information of DTT (ID: TT5ZKDI)

DTT Name Histone deacetylase 6 (HDAC6) DTT Info
UniProt ID
HDAC6_HUMAN
Gene Name HDAC6

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Patented Agent(s)
Investigative Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citarinostat DMQLODU Multiple myeloma 2A83 Phase 1 [1]
KA2507 DMW0H9Y Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
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77 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diaryl amine derivative 2 DMRBYAV N. A. N. A. Patented [2]
Diaryl amine derivative 3 DMLBN1T N. A. N. A. Patented [2]
Diaryl amine derivative 4 DMZL6AX N. A. N. A. Patented [2]
PMID28092474-Compound-32a DMGZ61E N. A. N. A. Patented [2]
PMID28092474-Compound-32b DMT2B5A N. A. N. A. Patented [2]
PMID28092474-Compound-32c DMGA3XL N. A. N. A. Patented [2]
PMID28092474-Compound-32d DMW21U4 N. A. N. A. Patented [2]
PMID28092474-Compound-32e DM8NHQS N. A. N. A. Patented [2]
PMID28092474-Compound-32f DMEIZ6Y N. A. N. A. Patented [2]
PMID28092474-Compound-32g DMTKLEP N. A. N. A. Patented [2]
PMID28092474-Compound-32h DME1WHT N. A. N. A. Patented [2]
PMID28092474-Compound-32i DMN3ZEF N. A. N. A. Patented [2]
PMID28092474-Compound-32j DMSGWTX N. A. N. A. Patented [2]
PMID28092474-Compound-32k DMHSJ65 N. A. N. A. Patented [2]
PMID28092474-Compound-32l DMSP5IA N. A. N. A. Patented [2]
PMID28092474-Compound-32m DMADMWB N. A. N. A. Patented [2]
PMID28092474-Compound-32n DMJO3RW N. A. N. A. Patented [2]
PMID28092474-Compound-32o DMV9BQN N. A. N. A. Patented [2]
PMID28092474-Compound-32p DM4ZO21 N. A. N. A. Patented [2]
PMID28092474-Compound-32q DMEASZY N. A. N. A. Patented [2]
PMID28092474-Compound-32r DMLTKMS N. A. N. A. Patented [2]
PMID28092474-Compound-32s DMS103B N. A. N. A. Patented [2]
PMID28092474-Compound-32t DM2JF0T N. A. N. A. Patented [2]
PMID28092474-Compound-32u DM805ZN N. A. N. A. Patented [2]
PMID28092474-Compound-32v DMHV3ES N. A. N. A. Patented [2]
PMID28092474-Compound-32x DML79XQ N. A. N. A. Patented [2]
PMID28092474-Compound-32y DMLR03U N. A. N. A. Patented [2]
PMID28092474-Compound-32z DMEPWGH N. A. N. A. Patented [2]
PMID28092474-Compound-33a DM7GH4Y N. A. N. A. Patented [2]
PMID28092474-Compound-33b DMIJQZV N. A. N. A. Patented [2]
PMID28092474-Compound-33c DM51JP6 N. A. N. A. Patented [2]
PMID28092474-Compound-33d DMW38MK N. A. N. A. Patented [2]
PMID28092474-Compound-33e DMGTSXL N. A. N. A. Patented [2]
PMID28092474-Compound-33f DMA360M N. A. N. A. Patented [2]
PMID28092474-Compound-33g DM18DY6 N. A. N. A. Patented [2]
PMID28092474-Compound-33h DM1DN6V N. A. N. A. Patented [2]
PMID28092474-Compound-33i DM16E95 N. A. N. A. Patented [2]
PMID28092474-Compound-33j DMNTRIZ N. A. N. A. Patented [2]
PMID28092474-Compound-33k DMF2ZNT N. A. N. A. Patented [2]
PMID28092474-Compound-33l DMPJSB2 N. A. N. A. Patented [2]
PMID28092474-Compound-33m DMXSPT9 N. A. N. A. Patented [2]
PMID28092474-Compound-33o DM6DJZ7 N. A. N. A. Patented [2]
PMID28092474-Compound-33p DMI8ZBK N. A. N. A. Patented [2]
PMID28092474-Compound-34a DMXQE7C N. A. N. A. Patented [2]
PMID28092474-Compound-34b DM6X2CO N. A. N. A. Patented [2]
PMID28092474-Compound-34c DMMI7DY N. A. N. A. Patented [2]
PMID29671355-Compound-11 DMNKABH N. A. N. A. Patented [3]
PMID29671355-Compound-13 DMALXYR N. A. N. A. Patented [3]
PMID29671355-Compound-14 DM8UMQH N. A. N. A. Patented [3]
PMID29671355-Compound-15 DMAEPD4 N. A. N. A. Patented [3]
PMID29671355-Compound-16 DM2C6ZF N. A. N. A. Patented [3]
PMID29671355-Compound-18 DMUY53P N. A. N. A. Patented [3]
PMID29671355-Compound-19 DM9LMNB N. A. N. A. Patented [3]
PMID29671355-Compound-21 DMPJN0M N. A. N. A. Patented [3]
PMID29671355-Compound-22 DMRGV83 N. A. N. A. Patented [3]
PMID29671355-Compound-23 DMUBOEX N. A. N. A. Patented [3]
PMID29671355-Compound-24 DMCIGJ1 N. A. N. A. Patented [3]
PMID29671355-Compound-25 DMPV0KZ N. A. N. A. Patented [3]
PMID29671355-Compound-26 DM5K6MG N. A. N. A. Patented [3]
PMID29671355-Compound-27 DMP7S9E N. A. N. A. Patented [3]
PMID29671355-Compound-28 DMLXSHW N. A. N. A. Patented [3]
PMID29671355-Compound-31 DM3H78D N. A. N. A. Patented [3]
PMID29671355-Compound-38a DMYATB5 N. A. N. A. Patented [3]
PMID29671355-Compound-38b DMYXE4J N. A. N. A. Patented [3]
PMID29671355-Compound-39 DM6EJ93 N. A. N. A. Patented [3]
PMID29671355-Compound-43 DMVPMWJ N. A. N. A. Patented [3]
PMID29671355-Compound-44 DM80A3V N. A. N. A. Patented [3]
PMID29671355-Compound-56 DM0VBMI N. A. N. A. Patented [3]
PMID29671355-Compound-61 DMXH1G3 N. A. N. A. Patented [3]
PMID29671355-Compound-62 DMWRS34 N. A. N. A. Patented [3]
PMID29671355-Compound-65a DMY3Q58 N. A. N. A. Patented [3]
PMID29671355-Compound-67 DM1RPL4 N. A. N. A. Patented [3]
PMID29671355-Compound-73 DMCNF36 N. A. N. A. Patented [3]
PMID29671355-Compound-74 DM49YTU N. A. N. A. Patented [3]
PMID29671355-Compound-8 DM7YQJK N. A. N. A. Patented [3]
PMID29671355-Compound-9 DMXL96M N. A. N. A. Patented [3]
Sulfonamide derivative 16 DMTFNGM N. A. N. A. Patented [4]
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⏷ Show the Full List of 77 Patented Agent(s)
92 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 Discovery agent N.A. Investigative [5]
(S)-2-Amino-N-cyclopentyl-7-mercaptoheptanamide DMDWFHV Discovery agent N.A. Investigative [6]
2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 Discovery agent N.A. Investigative [7]
4-Benzoylamino-N-hydroxy-benzamide DMYBPFS Discovery agent N.A. Investigative [8]
4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 Discovery agent N.A. Investigative [9]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 Discovery agent N.A. Investigative [10]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 Discovery agent N.A. Investigative [11]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ Discovery agent N.A. Investigative [12]
4-Phenylbutyrohydroxamic acid DMCZKN7 Discovery agent N.A. Investigative [13]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS Discovery agent N.A. Investigative [14]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL Discovery agent N.A. Investigative [7]
5-Mercapto-pentanoic acid phenylamide DMET3OJ Discovery agent N.A. Investigative [11]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD Discovery agent N.A. Investigative [11]
6-(9H-carbazol-9-yl)-N-hydroxyhexanamide DMVMDJ3 Discovery agent N.A. Investigative [15]
6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z Discovery agent N.A. Investigative [16]
6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 Discovery agent N.A. Investigative [16]
6-Mercapto-hexanoic acid phenylamide DMD2FW9 Discovery agent N.A. Investigative [11]
6-Phenoxy-hexane-1-thiol DMVYIN2 Discovery agent N.A. Investigative [11]
6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 Discovery agent N.A. Investigative [16]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY Discovery agent N.A. Investigative [5]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 Discovery agent N.A. Investigative [10]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P Discovery agent N.A. Investigative [5]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 Discovery agent N.A. Investigative [5]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV Discovery agent N.A. Investigative [11]
7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO Discovery agent N.A. Investigative [11]
7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK Discovery agent N.A. Investigative [11]
7-Mercapto-heptanoic acid phenylamide DM4912P Discovery agent N.A. Investigative [11]
7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA Discovery agent N.A. Investigative [11]
7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 Discovery agent N.A. Investigative [11]
7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide DM03XYF Discovery agent N.A. Investigative [6]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW Discovery agent N.A. Investigative [5]
8-Mercapto-octanoic acid phenylamide DMD3FWU Discovery agent N.A. Investigative [11]
8-Oxo-8-phenyl-octanoic acid DMXDQ25 Discovery agent N.A. Investigative [12]
8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL Discovery agent N.A. Investigative [10]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID Discovery agent N.A. Investigative [10]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 Discovery agent N.A. Investigative [10]
Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) DMZF35W Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) DMIVREK Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) DMLBECR Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) DMA76KW Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) DMLNJ0O Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) DMTVMWA Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) DMUSEDF Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) DMSEQ0W Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) DMBKP48 Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) DMVY89X Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) DMTDIM9 Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) DMV23XD Discovery agent N.A. Investigative [17]
Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) DM0VIH4 Discovery agent N.A. Investigative [17]
Cyclostellettamine derivative DMFTDPQ Discovery agent N.A. Investigative [18]
droxinostat DM5IA9W Discovery agent N.A. Investigative [19]
IKH-25 DM94AIL Solid tumour/cancer 2A00-2F9Z Investigative [20]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV Discovery agent N.A. Investigative [21]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ Discovery agent N.A. Investigative [21]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M Discovery agent N.A. Investigative [10]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT Discovery agent N.A. Investigative [12]
N-(6-Mercapto-hexyl)-benzamide DM01Y37 Discovery agent N.A. Investigative [11]
N-(biphenyl-3-yl)-6-(sulfamoylamino)hexanamide DMRCYB8 Discovery agent N.A. Investigative [22]
N-(quinolin-3-yl)-6-(sulfamoylamino)hexanamide DMYEQXH Discovery agent N.A. Investigative [22]
N-(quinolin-6-yl)-6-(sulfamoylamino)hexanamide DMFC3XI Discovery agent N.A. Investigative [22]
N-(quinolin-8-yl)-6-(sulfamoylamino)hexanamide DML8EVA Discovery agent N.A. Investigative [22]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A Discovery agent N.A. Investigative [8]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 Discovery agent N.A. Investigative [8]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 Discovery agent N.A. Investigative [8]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB Discovery agent N.A. Investigative [8]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY Discovery agent N.A. Investigative [8]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT Discovery agent N.A. Investigative [8]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY Discovery agent N.A. Investigative [9]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 Discovery agent N.A. Investigative [9]
N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 Discovery agent N.A. Investigative [8]
N-phenyl-6-(sulfamoylamino)hexanamide DMRHKF8 Discovery agent N.A. Investigative [22]
N-[5-(Formyl-hydroxy-amino)-pentyl]-benzamide DMH7QOF Discovery agent N.A. Investigative [23]
N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide DMMQXON Discovery agent N.A. Investigative [22]
N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide DMZA8NC Discovery agent N.A. Investigative [24]
N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide DMOZARM Discovery agent N.A. Investigative [24]
nexturastat A DM6NS7H Discovery agent N.A. Investigative [25]
NILTUBACIN DM0QJSO Discovery agent N.A. Investigative [13]
NQN-1 DMAXHLK Discovery agent N.A. Investigative [26]
Octanedioic acid bis-hydroxyamide DMJNQ9K Discovery agent N.A. Investigative [27]
Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 Discovery agent N.A. Investigative [12]
Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK Discovery agent N.A. Investigative [12]
PMID19111466C7d DMVTXKI Discovery agent N.A. Investigative [28]
PMID20947351C16 DM02YSE Discovery agent N.A. Investigative [15]
PSAMMAPLIN A DM6T0IQ Discovery agent N.A. Investigative [10]
santacruzamate A DMFAM7P Discovery agent N.A. Investigative [29]
ST-2741 DM73E0G Discovery agent N.A. Investigative [30]
ST-2986 DMNERM6 Discovery agent N.A. Investigative [31]
ST-2987 DMWXTM8 Solid tumour/cancer 2A00-2F9Z Investigative [31]
ST-3050 DM19K2D Discovery agent N.A. Investigative [31]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF Discovery agent N.A. Investigative [11]
Tubacin DMYR8SG Multiple myeloma 2A83 Investigative [32], [33]
UCL-67022 DMFYUMX Multiple myeloma 2A83 Investigative [20]
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⏷ Show the Full List of 92 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236.
3 HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17.
4 Sulfonamide inhibitors: a patent review 2013-present.Expert Opin Ther Pat. 2018 Jul;28(7):541-549.
5 Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13.
6 Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38.
7 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7.
8 Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
9 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74.
10 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
11 Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32.
12 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7.
13 Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243.
14 Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.
15 Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70.
16 Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
17 Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9.
18 Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.
19 Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
20 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618).
21 Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.
22 Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40.
23 Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorg Med Chem Lett. 2004 Jan 19;14(2):449-53.
24 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6.
25 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.
26 A novel class of small molecule inhibitors of HDAC6. ACS Chem Biol. 2012 Feb 17;7(2):331-9.
27 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309.
28 Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92.
29 Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
30 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3.
31 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9.
32 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
33 Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.