Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6CQUM)

• DTT Name: B7 homolog 3 (CD276) DTT Info
• Gene Name: CD276

Molecule-Related Drug & Molecule List

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
131 I-omburtamab	DM12UX6	Brain and central nervous system tumour	2A00.11	Phase 2/3	[1]
Omburtamab	DMTIESG	Neuroblastoma	2D11.2	Phase 2/3	[2]
Omburtamab I-131	DMPDA17	Neuroblastoma	2D11.2	Phase 2/3	[3]
Enoblituzumab	DMDS20X	Prostate cancer	2C82.0	Phase 2	[4]
TAK-280	DM08RE5	Aggressive cancer	2A00-2F9Z	Phase 2	[5]
DS-7300	DMK4VY9	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[6]
MGC018	DM1KZW0	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[7]
Omburtamab I-124	DMPLBDF	Glioma	2A00.0	Phase 1/2	[3]
124I-8H9	DM5ZC0E	Glioblastoma multiforme	2A00.0	Phase 1	[8]
MGA271	DM2PVLH	Metastatic cancer	2D50-2E2Z	Phase 1	[9]
MGD009	DME4B8I	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

References

• [1] IntraOmmaya compartmental radioimmunotherapy using 131 I-omburtamab-pharmacokinetic modeling to optimize therapeutic index. Eur J Nucl Med Mol Imaging. 2021 Apr;48(4):1166-1177.
• [2] Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. Cancer Immunol Immunother. 2021 Feb 3.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] ClinicalTrials.gov (NCT05220098) A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of TAK-280 in Patients With Unresectable Locally Advanced or Metastatic Cancer. U.S.National Institutes of Health.
• [6] Clinical pipeline report, company report or official report of Daiichi Sankyo.
• [7] Clinical pipeline report, company report or official report of MacroGenics.
• [8] National Cancer Institute Drug Dictionary (drug id 722029).
• [9] T Cell Coinhibition and Immunotherapy in Human Breast Cancer. Discov Med. 2012 October; 14(77): 229-236.