Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT72OKI)

• DTT Name: P2Y purinoceptor 14 (P2RY14) DTT Info
• Gene Name: P2RY14

Molecule-Related Drug & Molecule List

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-thio-UDP	DM84R6C	Discovery agent	N.A.	Investigative	[1]
alpha.beta-methylene-2-thio-UDP	DMLGMTQ	Discovery agent	N.A.	Investigative	[1]
MRS2690	DMNS3RT	Discovery agent	N.A.	Investigative	[2]
MRS2802	DMWKZCY	Discovery agent	N.A.	Investigative	[1]
MRS2905	DMGCPHO	Discovery agent	N.A.	Investigative	[3]
PPTN	DML72JT	Discovery agent	N.A.	Investigative	[4]
UDP-glucose	DMLT4JA	Discovery agent	N.A.	Investigative	[5]
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[6]

References

• [1] Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.
• [2] The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40.
• [3] Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.
• [4] A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.
• [5] Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8.
• [6] Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8.