General Information of DTT (ID: TT85VHW)

DTT Name MERS-CoV spike glycoprotein (S) DTT Info
Gene Name MERS-CoV S

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [1]
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2 Discontinued Drugs Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
REGN 3048 DMW08TD Middle East Respiratory Syndrome (MERS) 1D64 Discontinue in Phase 1 Trial [2]
REGN 3051 DMLH28J Middle East Respiratory Syndrome (MERS) 1D64 Discontinue in Phase 1 Trial [2]
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7 Preclinical Drugs Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alpha-Helical lipopeptides FFS DMATQB7 Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Alpha-Helical lipopeptides IIK DMVSKQF Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Alpha-Helical lipopeptides IIS DM1MGBX Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Alpha-Helical lipopeptides LLS DM3WVM4 Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
MERS-five-helix bundle DMG5YRP Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [4]
Peptide P21S10 DMMWQTI Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [5]
PMID26911565-peptide-P9 DMUH012 Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [6]
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⏷ Show the Full List of 7 Preclinical Drugs
Molecule Interaction Atlas

References

1 Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539.
2 Pre- And Postexposure Efficacy of Fully Human Antibodies Against Spike Protein in a Novel Humanized Mouse Model of MERS-CoV Infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112.
3 De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745.
4 Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus. Viruses. 2017 Sep 14;9(9). pii: E255.
5 Discovery of Hydrocarbon-Stapled Short -Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. J Med Chem. 2018 Mar 8;61(5):2018-2026.
6 A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008.