Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTA0P7K)

• DTT Name: Complement factor B (CFB) DTT Info
• Gene Name: CFB

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Iptacopan	DM9EZM0	Paroxysmal nocturnal haemoglobinuria	3A21.0	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LPN023	DM7BN5W	IgA nephropathy	MF8Y	Phase 2	[2]
RG6299	DMVJL8W	Geographic atrophy	9B75	Phase 2	[3]
SAR443809	DMSUQTW	Discovery agent	N.A.	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CAB-2	DMQ4HUA	Coronary artery disease	BA80	Discontinued in Phase 1	[5]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NM-9308	DMC89HI	Age-related macular degeneration	9B75.0	Investigative	[6]
PMID19743866C51	DMTX0ZJ	Discovery agent	N.A.	Investigative	[7]
TA-106	DME2PFQ	Asthma	CA23	Investigative	[6]

References

• [1] Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722.
• [2] Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol. 2019 Sep 27;10:2166.
• [3] Clinical pipeline report, company report or official report of Roche
• [4] Clinical pipeline report, company report or official report of Sanofi
• [5] A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).
• [7] Structure-activity relationships for substrate-based inhibitors of human complement factor B. J Med Chem. 2009 Oct 8;52(19):6042-52.