Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTA592U)

• DTT Name: Urate anion exchanger 1 (URAT1) DTT Info
• UniProt ID: S22AC_HUMAN
• Gene Name: SLC22A12

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lesinurad	DMUR64T	Hyperuricaemia	5C55.Y	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RDEA-684	DMNWYHD	Gout	FA25	Phase 2	[1]
RDEA3170	DM1TKG4	Hyperuricaemia	5C55.Y	Phase 2	[2]
URC102	DMY89BN	Gout	FA25	Phase 2	[3]

18 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-ethyl-3-(4-hydroxy) benzoyl benzofuran derivative 1	DMHYIAV	N. A.	N. A.	Patented	[4]
3-benzyloxyphenyloxoacetic acid derivative 1	DMB6M3Y	N. A.	N. A.	Patented	[4]
Benzene sulfonamide derivative 16	DMATBZW	N. A.	N. A.	Patented	[4]
Benzofurans derivative 1	DM4198Z	N. A.	N. A.	Patented	[4]
Benzoic acid derivative 1	DM5ZKR2	N. A.	N. A.	Patented	[4]
Cycloalkyl acid derivative 1	DMXMGSP	N. A.	N. A.	Patented	[4]
Cycloalkyl acid derivative 2	DM09LY3	N. A.	N. A.	Patented	[4]
Fused heterocyclic compound 12	DMSYD6Z	N. A.	N. A.	Patented	[4]
Phenylthioacetate derivative 1	DMTHXUC	N. A.	N. A.	Patented	[4]
PMID27414413-Compound-Figure6right	DMUG9X0	N. A.	N. A.	Patented	[4]
PMID27414413-Compound-Figure8right	DMTZNSM	N. A.	N. A.	Patented	[4]
Ring-fused compound 1	DMUB7RV	N. A.	N. A.	Patented	[4]
Succinamide derivative 1	DMTXDSG	N. A.	N. A.	Patented	[4]
Sulfonamide derivative 10	DMA32GJ	N. A.	N. A.	Patented	[4]
Sulfonamide derivative 11	DMJBR86	N. A.	N. A.	Patented	[4]
Tetrazole acetic acid derivative 1	DM52683	N. A.	N. A.	Patented	[4]
Tihoacetate derivative 1	DM6QHO0	N. A.	N. A.	Patented	[4]
Triazole propanedioic acid derivative 1	DM8LFGS	N. A.	N. A.	Patented	[4]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Morin	DM2OGZ5	Discovery agent	N.A.	Investigative	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1031).
• [2] The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 2013; 14: 164.
• [3] Clinical pipeline report, company report or official report of Chugai Pharmaceutical (2013).
• [4] Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10.
• [5] Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) express... Drug Metab Dispos. 2007 Jun;35(6):981-6.