Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTB7VAT)

• DTT Name: Serum amyloid P-component (APCS) DTT Info
• Gene Name: APCS

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zinpentraxin alfa	DMNJAVV	Idiopathic pulmonary fibrosis	CB03.4	Phase 3	[1]
CPHPC	DM1ZGUX	Parkinson disease	8A00.0	Phase 1/2	[2]
GSK-2315698	DMOWTRL	Amyloidosis	5D00	Phase 1	[3]
GSK2398852	DMZ5A6D	Amyloidosis	5D00	Phase 1	[4]

References

• [1] Safety and efficacy of zinpentraxin alfa as monotherapy or in combination with ruxolitinib in myelofibrosis: stage I of a phase II trial. Haematologica. 2023 Oct 1;108(10):2730-2742.
• [2] Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).Acta Crystallogr D Biol Crystallogr.2014 Aug;70(Pt 8):2232-40.
• [3] Target Mediated Drug Disposition Model of CPHPC in Patients with Systemic Amyloidosis. CPT Pharmacometrics Syst Pharmacol. 2015 February; 4(2): e15.
• [4] ClinicalTrials.gov (NCT01777243) A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis. U.S. National Institutes of Health.