Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTC24WT)

• DTT Name: C-C chemokine receptor type 1 (CCR1) DTT Info
• Gene Name: CCR1

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-817399	DMT8L6P	Rheumatoid arthritis	FA20	Phase 2	[1]
CCX-354	DMSHV9C	Autoimmune diabetes	5A10	Phase 2	[2]
AVE1701	DMJY35M	Rheumatoid arthritis	FA20	Phase 1	[3]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD4818	DM3VFKM	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[4]
MLN3897	DMRA3EZ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[3]
COSALANE	DMO3486	N. A.	N. A.	Terminated	[5]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A-987306	DMU34BK	Discovery agent	N.A.	Investigative	[6]
BX 471	DM5CGXB	Discovery agent	N.A.	Investigative	[7]
Cosalane derivative	DMSFXJ8	Discovery agent	N.A.	Investigative	[5]

References

• [1] Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014 Sep 25;57(18):7550-64.
• [2] Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis. 2013 Mar;72(3):337-44.
• [3] Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
• [4] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [5] Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorg Med Chem Lett. 2001 Jan 8;11(1):59-62.
• [6] cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
• [7] Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.