Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCGOIN)

• DTT Name: PIM-3 protein kinase (PIM3) DTT Info
• Gene Name: PIM3

Molecule-Related Drug & Molecule List

31 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BDBM50061601	DMQ4TUE	N. A.	N. A.	Patented	[1]
BDBM50061608	DM3MRD9	N. A.	N. A.	Patented	[1]
BDBM50061612	DMM8IDC	N. A.	N. A.	Patented	[1]
N-{4	DM6R34M	N. A.	N. A.	Patented	[2]
US8481586, 15	DMFEUMZ	N. A.	N. A.	Patented	[3]
US8481586, 40	DM6U3ZR	N. A.	N. A.	Patented	[3]
US8481586, 5	DM5W0A2	N. A.	N. A.	Patented	[3]
US8592455, 3	DMY8U6J	N. A.	N. A.	Patented	[2]
US8592455, 90	DMTE8QO	N. A.	N. A.	Patented	[2]
US8669361, 102	DM4G3OC	N. A.	N. A.	Patented	[4]
US8669361, 103	DMC67G4	N. A.	N. A.	Patented	[5]
US8669361, 105	DMIZWM6	N. A.	N. A.	Patented	[5]
US8669361, 107	DMF8MIB	N. A.	N. A.	Patented	[5]
US8759338, 1	DMRHNIL	N. A.	N. A.	Patented	[6]
US8759338, 12	DMXHN1V	N. A.	N. A.	Patented	[6]
US8759338, 2	DMSBRHJ	N. A.	N. A.	Patented	[6]
US8829193, 1	DMWKDET	N. A.	N. A.	Patented	[7]
US8829193, 2	DMBIAQD	N. A.	N. A.	Patented	[7]
US8829193, 3	DM5ZGK3	N. A.	N. A.	Patented	[7]
US8889696, Staurosporine	DMSYUHK	N. A.	N. A.	Patented	[8]
US8987457, 117	DM4MRP9	N. A.	N. A.	Patented	[9]
US8987457, 15	DMAGNEH	N. A.	N. A.	Patented	[9]
US8987457, 198	DM0O8WS	N. A.	N. A.	Patented	[9]
US9434725, 113	DMS842X	N. A.	N. A.	Patented	[10]
US9434725, 285	DM6Z01B	N. A.	N. A.	Patented	[10]
US9434725, 315	DM316FB	N. A.	N. A.	Patented	[10]
US9580418, Example 11	DMJ76RC	N. A.	N. A.	Patented	[11]
US9580418, Example 8	DMGH9B3	N. A.	N. A.	Patented	[11]
US9682991, 2	DMVGQXK	N. A.	N. A.	Patented	[12]
US9682991, 23	DMGTIP6	N. A.	N. A.	Patented	[12]
US9682991, 7	DM7SQKD	N. A.	N. A.	Patented	[12]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID21982499C14k	DM0VOXN	Discovery agent	N.A.	Investigative	[13]
PMID22136433C20	DMI8217	Discovery agent	N.A.	Investigative	[14]
PMID24900749C1a	DMZPUSO	Discovery agent	N.A.	Investigative	[15]

References

• [1] Azole compounds as PIM inhibitors. US9321756.
• [2] Kinase inhibitors and methods of their use. US8592455.
• [3] Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586.
• [4] Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US9573943.
• [5] Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US8669361.
• [6] Heterocyclic kinase inhibitors. US8759338.
• [7] PIM kinase inhibitors and methods of their use. US8829193.
• [8] Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696.
• [9] Ring-substituted N-pyridinyl amides as kinase inhibitors. US8987457.
• [10] 5-azaindazole compounds and methods of use. US9434725.
• [11] Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors. US9580418.
• [12] Tricyclic compounds for use as kinase inhibitors. US9682991.
• [13] 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92.
• [14] 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.
• [15] Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5.