Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTDL0NY)

• DTT Name: Carnitine O-palmitoyltransferase I (CPT1B) DTT Info
• Gene Name: CPT1B

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[1]
Perhexiline	DMINO7Z	Angina pectoris	BA40	Approved	[2]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SDZ-CPI-975	DM70MJQ	Diabetic complication	5A2Y	Discontinued in Phase 1	[3]
DB-200	DMTXPSB	Psoriasis vulgaris	EA90	Terminated	[4]
Etomoxir	DM3BHN1	Heart failure	BD10-BD13	Terminated	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
C75	DMHGX1N	Obesity	5B81	Investigative	[6]

References

• [1] Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology. 2009 Oct;150(10):4562-74.
• [2] Perhexiline. Cardiovasc Drug Rev. 2007 Spring;25(1):76-97.
• [3] Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. Am J Physiol. 1998 Feb;274(2 Pt 2):R524-8.
• [4] Comparison of the effects of carnitine palmitoyltransferase-1 and -2 inhibitors on rat heart hypertrophy. Cardioscience. 1994 Sep;5(3):193-7.
• [5] Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988 Dec;63(6):1036-43.
• [6] C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.