General Information of DTT (ID: TTG5QB7)

DTT Name Calpain-2 (CAPN2) DTT Info
Gene Name CAPN2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-957 DMB9N4J Alzheimer disease 8A20 Phase 1 [1]
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19 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
5-azolone derivative 1 DMN2B87 N. A. N. A. Patented [2]
Carboxamide derivative 10 DM5WMO9 N. A. N. A. Patented [2]
Carboxamide derivative 11 DM1DN94 N. A. N. A. Patented [2]
Carboxamide derivative 5 DM149WN N. A. N. A. Patented [2]
Carboxamide derivative 6 DM6GZW4 N. A. N. A. Patented [2]
Carboxamide derivative 7 DM8TQS4 N. A. N. A. Patented [2]
Carboxamide derivative 8 DM6HI34 N. A. N. A. Patented [2]
Carboxamide derivative 9 DMVISYC N. A. N. A. Patented [2]
Epoxysuccinate derivative 1 DMU8LPN N. A. N. A. Patented [2]
Epoxysuccinate derivative 10 DMYF39U N. A. N. A. Patented [2]
Epoxysuccinate derivative 2 DMEV9O3 N. A. N. A. Patented [2]
Epoxysuccinate derivative 3 DMMETW5 N. A. N. A. Patented [2]
Epoxysuccinate derivative 4 DMCF6M8 N. A. N. A. Patented [2]
Epoxysuccinate derivative 5 DM37MCN N. A. N. A. Patented [2]
Epoxysuccinate derivative 6 DMQM6ZS N. A. N. A. Patented [2]
Epoxysuccinate derivative 7 DMTSPVF N. A. N. A. Patented [2]
Epoxysuccinate derivative 8 DMQTVPC N. A. N. A. Patented [2]
Epoxysuccinate derivative 9 DM49FU0 N. A. N. A. Patented [2]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [2]
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⏷ Show the Full List of 19 Patented Agent(s)
5 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BITHIONOL DMPJKRL Trematode infection 1F8Y Withdrawn from market [3]
Aloxistatin DMGW07M Neurological disorder 6B60 Discontinued in Phase 3 [3]
AK-295 DM51NI0 Cerebral infarction 8B11.5Z Terminated [4]
MDL-28170 DMYK31O Alzheimer disease 8A20 Terminated [5]
SJA-6017 DM6X430 N. A. N. A. Terminated [6]
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12 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(1-Benzyl-2-oxo-ethyl)-carbamic acid benzyl ester DMWK3RO Discovery agent N.A. Investigative [7]
3-(1H-Pyrrol-3-yl)-propionamide DMCKJ27 Discovery agent N.A. Investigative [8]
A-558693 DMN320E Neurological disorder 6B60 Investigative [4]
AW-00430 DMG6LJ8 Discovery agent N.A. Investigative [3]
Calpastatin DMR0CNQ Discovery agent N.A. Investigative [9]
DIHYDROXANTHOHUMOL DMFKWRM Discovery agent N.A. Investigative [3]
GNF-PF-4453 DMPYIA3 Discovery agent N.A. Investigative [3]
mercaptoacrylate inhibitor of calpain 1 DMZIA1R Discovery agent N.A. Investigative [4]
N-(1-Benzyl-2-oxo-ethyl)-benzamide DMP9A7L Discovery agent N.A. Investigative [7]
PMID20690647C4b DMKVONZ Discovery agent N.A. Investigative [10]
PMID20690647C5a DMRWZX6 Discovery agent N.A. Investigative [10]
PMID8831774C19 DMM08LV Discovery agent N.A. Investigative [11]
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⏷ Show the Full List of 12 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
2 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.
3 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336).
5 Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8.
6 Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6911-23.
7 Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases. J Med Chem. 1990 Jan;33(1):11-3.
8 Synthesis of cystamidin a (pyrrole-3-propanamide), a reported calpain inhibitor, Bioorg. Med. Chem. Lett. 6(13):1541-1542 (1996).
9 Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors. Brain Res Brain Res Rev. 2003 May;42(2):169-85.
10 Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J Med Chem. 2010 Sep 9;53(17):6326-36.
11 Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem. 1996 Sep 27;39(20):4089-98.