Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGW72V)

• DTT Name: Interleukin-12 beta (IL12B) DTT Info
• Gene Name: IL12B

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[1]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-874	DMYHSO2	Plaque psoriasis	EA90.0	Phase 3	[2]
EGEN-001	DM6L5TR	Fallopian tube cancer	2C74	Phase 2	[3]
SFV IL-12 gene therapy	DMVIWNK	Breast cancer	2C60-2C65	Phase 2	[4]
Ad-IL-12 DNA therapeutic	DMB19IO	Melanoma	2C30	Phase 1/2	[5]
NHS-IL 12	DMU6CQ7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
PF-07261271	DM0K4WQ	Inflammatory bowel disease	DD72	Phase 1	[7]

References

• [1] A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
• [2] Briakinumab for the treatment of plaque psoriasis.BioDrugs.2012 Feb 1;26(1):9-20.
• [3] National Cancer Institute Drug Dictionary (drug id 454593).
• [4] Clinical pipeline report, company report or official report of Trademarkia.
• [5] National Cancer Institute Drug Dictionary (drug id 710508).
• [6] The immunocytokine NHS-IL12 as a potential cancer therapeutic. Oncotarget. 2014 Apr 15;5(7):1869-84.
• [7] Clinical pipeline report, company report or official report of Pfizer